Oxycodone Side Effects

It is possible that some side effects of oxycodone may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

For the Consumer

Applies to oxycodone: oral capsule, oral solution, oral tablet, oral tablet extended release

Along with its needed effects, oxycodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oxycodone:

Less common
  • Chills
  • cold sweats
  • confusion
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fever
  • tightness in the chest
  • twitching
Rare
  • Abdominal or stomach pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine
  • burning while urinating burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • convulsions
  • cough
  • decrease in the frequency of urination
  • decrease in urine volume
  • decreased urine output
  • difficult or painful urination
  • difficulty in passing urine (dribbling)
  • difficulty with swallowing
  • dizziness
  • dry mouth
  • fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth or heat
  • flushing or redness of the skin, especially on the face and neck
  • frequent urination
  • headache
  • hives
  • increase in heart rate
  • increased thirst
  • increased volume of pale, dilute urine
  • itching
  • lightheadedness
  • muscle pain or cramps
  • nausea or vomiting
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid breathing
  • rapid weight gain
  • severe constipation
  • severe vomiting
  • shakiness in the legs, arms, hands, or feet
  • skin rash
  • sunken eyes
  • sweating
  • swelling or puffiness of the face
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • thirst
  • tingling of the hands or feet
  • trembling or shaking of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • wrinkled skin
Incidence not known
  • Blurred vision
  • choking
  • clay-colored stools
  • cold, clammy skin
  • dark urine
  • diarrhea
  • fast, weak pulse
  • gagging
  • irregular, fast, slow, or shallow breathing
  • loss of appetite
  • low blood pressure or pulse
  • pale or blue lips, fingernails, or skin
  • unconsciousness
  • unpleasant breath odor
  • very slow breathing
  • very slow heartbeat
  • yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking oxycodone:

Symptoms of overdose
  • Change in consciousness
  • chest pain or discomfort
  • constricted, pinpoint, or small pupils (black part of the eye)
  • decreased awareness or responsiveness
  • extreme drowsiness
  • loss of consciousness
  • no muscle tone or movement
  • severe sleepiness
  • slow or irregular heartbeat

Some side effects of oxycodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Difficulty having a bowel movement (stool)
  • drowsiness
  • lack or loss of strength
  • relaxed and calm feeling
  • sleepiness or unusual drowsiness
Less common
  • Abnormal dreams
  • acid or sour stomach
  • anxiety
  • belching
  • burning feeling in the chest or stomach
  • false or unusual sense of well-being
  • heartburn
  • hiccups
  • indigestion
  • stomach discomfort, upset, or pain
  • tenderness in the stomach area
  • trouble sleeping
  • weight loss
Rare
  • Absent, missed, or irregular menstrual periods
  • bad, unusual or unpleasant (after) taste
  • bloated or full feeling
  • body aches or pain
  • change in taste
  • change in walking and balance
  • changes in vision
  • clumsiness or unsteadiness
  • congestion
  • continuing ringing or buzzing or other unexplained noise in the ears
  • cracks in the skin
  • crying
  • decreased interest in sexual intercourse
  • dental caries or tooth decay
  • depersonalization
  • depression
  • difficulty with speaking
  • dry skin
  • dryness or soreness of the throat
  • dysphoria
  • excess air or gas in the stomach or intestines
  • excessive muscle tone
  • feeling of constant movement of self or surroundings
  • feeling of unreality
  • general feeling of discomfort or illness
  • headache, severe and throbbing
  • hearing loss
  • hives or welts
  • hoarseness
  • hyperventilation
  • inability to have or keep an erection
  • increase in body movements
  • increased appetite
  • increased cough
  • irritability
  • loss in sexual ability, desire, drive, or performance
  • loss of heat from the body
  • loss of memory
  • loss of strength or energy
  • mental depression
  • muscle pain or weakness
  • muscle stiffness
  • muscle tension or tightness
  • neck pain
  • paranoia
  • passing of gas
  • problems with memory
  • quick to react or overreact emotionally
  • rapidly changing moods
  • red, swollen skin
  • restlessness
  • runny nose
  • scaly skin
  • sensation of spinning
  • sense of detachment from self or body
  • severe sleepiness
  • stomach pain, fullness, or discomfort
  • stopping of menstrual bleeding
  • swelling or inflammation of the mouth
  • tender, swollen glands in the neck
  • unusual weak feeling
  • voice changes

For Healthcare Professionals

Applies to oxycodone: compounding powder, oral capsule, oral concentrate, oral solution, oral tablet, oral tablet extended release

General

In general, the adverse effects that occur with oxycodone are similar with the immediate- and controlled-release products. Adverse effects may be dose-related in opioid naive patients. Patients who are tolerant to the analgesic effect of oxycodone may be tolerant to the dose-related side effects, except constipation.

Nervous system

Nervous system side effects are common and include drowsiness (23% to 24%), sedation, dizziness (13% to 16%), headache (7%). dry mouth (7%), and lightheadedness. Many of the central nervous system adverse effects may be minimized by slow titration of the dose.

Respiratory

Respiratory depression may occur with any opioid, including oxycodone. Other effects may include apnea, respiratory arrest, and rarely circulatory collapse.

Severe adverse effects such as respiratory depression can be treated with the opioid antagonist naloxone. (The usual adult dose of naloxone is 1 to 2 mg every 5 minutes as necessary to a maximum of 10 mg. The dose can be administered intravenously, intramuscularly, subcutaneously, and sublingually.)

Gastrointestinal

Nausea (23% to 27%), vomiting (12% to 14%), and constipation (23% to 26%) occur commonly. There have been rare reports of difficulty in swallowing the tablets, intestinal obstruction, and exacerbation of diverticulitis, some of which have required medical intervention to remove the tablet. Patients with underlying GI disorders such as esophageal cancer or colon cancer with a small gastrointestinal lumen are at greater risk of developing these complications.

Other

Withdrawal symptoms, after either abrupt cessation or fast tapering of narcotic analgesics, may occur and include agitation, palpitations, restlessness, anxiety, insomnia, tremor, abdominal cramps, blurred vision, vomiting, piloerection, and sweating.

Psychosis has also been reported during withdrawal from oxycodone.

Psychiatric

Psychiatric adverse effects reported include paranoia, psychosis, and hallucinations.

Dermatologic

Pruritus has been reported rarely. Diphenhydramine (25 to 50 mg) has been shown to be helpful for opioid-associated pruritus.

Hepatic

Hepatic side effects including increased hepatic enzymes have been reported.

Cardiovascular

Cardiovascular side effects from higher doses have included QTc prolongation.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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