Generic Name: granisetron (gra-NIS-e-tron)
Brand Name: Kytril

Kytril is used for:

Preventing nausea and vomiting caused by cancer chemotherapy and surgery. It may also be used for other conditions as determined by your doctor.

Kytril is a 5-HT3 receptor antagonist. It works by blocking a chemical called serotonin that can cause vomiting.

Do NOT use Kytril if:

  • you are allergic to any ingredient in Kytril
  • you are taking apomorphine

Contact your doctor or health care provider right away if any of these apply to you.

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Before using Kytril:

Some medical conditions may interact with Kytril. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are allergic to other 5-HT3 receptor antagonists (eg, ondansetron)
  • if you have heart problems (eg, irregular heartbeat, conduction problems), blood electrolyte problems (eg, low calcium, potassium, or magnesium), an abnormal electrocardiogram (ECG), or you are receiving chemotherapy that may cause heart problems
  • if you have stomach or bowel problems (eg, pain, swelling) or if you have recently had stomach surgery

Some MEDICINES MAY INTERACT with Kytril. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Apomorphine because the risk of side effects, such as severely low blood pressure or loss of consciousness, may occur
  • Medicines that may affect your heartbeat such as antiarrhythmics (eg, flecainide, sotalol), azole antifungals (eg, ketoconazole), or quinolones (eg, ciprofloxacin) because heart rhythm problems may occur. Ask your doctor if you are unsure if any medicines that you take may affect your heartbeat

This may not be a complete list of all interactions that may occur. Ask your health care provider if Kytril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Kytril:

Use Kytril as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Kytril is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Kytril at home, a health care provider will teach you how to use it. Be sure you understand how to use Kytril. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Kytril if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Kytril, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Kytril.

Important safety information:

  • Kytril may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Kytril with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Some forms of this product contain benzyl alcohol, which may cause a severe and sometimes fatal reaction known as "gasping syndrome" in premature, newborn, or low birth-weight infants. Ask your doctor or pharmacist if Kytril contains benzyl alcohol. Use Kytril with extreme caution in premature, newborn, or low birth-weight infants.
  • Kytril should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Kytril while you are pregnant. It is not known if Kytril is found in breast milk. If you are or will be breast-feeding while you are using Kytril, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Kytril:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Agitation; anxiety; constipation; diarrhea; dizziness; drowsiness; headache; indigestion; nausea; pain, swelling, or redness at the injection site; stomach pain; taste changes; trouble sleeping; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast or irregular heartbeat; fever, chills, or sore throat; unusual muscle movement.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include headache.

Proper storage of Kytril:

Kytril is usually handled and stored by a health care provider. If you are using Kytril at home, store Kytril as directed by your pharmacist or health care provider. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Kytril out of the reach of children and away from pets.

General information:

  • If you have any questions about Kytril, please talk with your doctor, pharmacist, or other health care provider.
  • Kytril is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Kytril or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Kytril. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Kytril. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Kytril.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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