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ProMectin B Pour-On For Cattle

This page contains information on ProMectin B Pour-On For Cattle for veterinary use.
The information provided typically includes the following:
  • ProMectin B Pour-On For Cattle Indications
  • Warnings and cautions for ProMectin B Pour-On For Cattle
  • Direction and dosage information for ProMectin B Pour-On For Cattle

ProMectin B Pour-On For Cattle

This treatment applies to the following species:
Company: Vedco


Contains 5 mg ivermectin/mL

Kills: Roundworms (including Brown Stomach Worm), Lungworms, Grubs, Sucking Lice, Biting Lice, Mange Mites, Horn Flies

ANADA 200-219, Approved by FDA


Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.


ProMectin® B (ivermectin) Pour-On delivers internal and external parasite control in one convenient low-volume application. Ivermectin is a potent antiparasitic agent whose chemical structure is different from those of other antiparasitic agents.

ProMectin B Pour-On For Cattle Indications

ProMectin® B Pour-On applied at the recommended dose level of 500 mcg/kg is indicated for the effective control of these parasites.

Gastrointestinal Roundworms

Ostertagia ostertagi (including inhibited stage) (adults and L4), Haemonchus placei (adults and L4), Trichostrongylus axei (adults and L4), T. colubriformis (adults and L4), Cooperia oncophora (adults and L4), Cooperia punctata (adults and L4), Cooperia surnabada (adults and L4), Strongyloides papillosus (adults), Oesophagostomum radiatum (adults and L4), Trichuris spp (adults)


Dictyocaulus viviparus (adults and L4)

Cattle Grubs

(parasitic stages) - Hypoderma bovis, H. lineatum


Sarcoptes scabiei var. bovis


Linognathus vituli, Haematopinus eurysternus, Damalinia bovis, Solenopotes capillatus

Horn Flies

Haematobia irritans

Persistent Activity

ProMectin® B Pour-On has been proved to effectively control infections and to protect cattle from re-infection with Ostertagia ostertagi, Oesophagostomum radiatum, Haemonchus placei, Trichostrongylus axei, Cooperia punctata and Cooperia oncophora for 14 days after treatment.

Treatment For Cattle For Horn Flies

ProMectin® B Pour-On controls horn flies (Haematobia irritans) for up to 28 days after dosing. For best results, ProMectin® B Pour-On should be part of a parasite control program for both internal and external parasites based on the epidemiology of these parasites. Consult your veterinarian or an entomologist for the most effective timing of applications.


The dose rate is 1 mL for each 22 lb of body weight. The formulation should be applied along the topline in a narrow strip extending from the withers to the tailhead.


Dispensing Cap (250 mL bottles) - The product’s enclosed dispensing cap is graduated in 5 mL increments. Each 5 mL will treat 110 lbs body weight. When body weight is between markings, use the next higher increment.

Attach the dispensing cap to the bottle.

Select the correct dose rate by rotating the adjuster top in either direction to position the dose indicator to the appropriate level.

Hold the bottle upright and gently squeeze it to deliver a slight excess of the required dose as indicated by the calibration lines.

By releasing the pressure, the dose automatically adjusts to the correct level. Tilt the bottle to deliver the dose. The off (stop) position will close the system between dosing.

Applicator Gun*

Because of the solvents used in ProMectin® B (ivermectin) Pour-On, only the ProMectin® B (ivermectin) applicator gun, or equivalent, is recommended. Other applicators may exhibit compatibility problems, resulting in locking, incorrect dosage or leakage.

(5 L backpack) - Remove the draw-off cap and the backpack strap from the indentation in the back of the bottle and refer to the diagram to fit the strap to the bottle.

Thread the strap through the bottle eyelet number 1, then 2, 3, and 4, taking care to follow the diagram when connecting the strap to the buckle.

The strap is adjustable by lifting the tab on the buckle.

Slide one of the coil springs over one end of the draw-off tubing. Attach that end of the draw-off tubing to the stem on the applicator gun and slide the spring up to the connection. Slide the second coil spring over the other end of the draw-off tubing and connect that end to the cap that has the stem. Slide the spring to the connection. Replace the shipping cap with the cap having the draw-off tubing attached. Tighten this draw-off cap to the bottle. Invert the bottle and use as a backpack.

Follow the applicator gun manufacturer’s directions for priming the gun, adjusting the dose, and care of the applicator gun following use.



220 lb (100 kg)

10 mL

330 lb (150 kg)

15 mL

440 lb (200 kg)

20 mL

550 lb (250 kg)

25 mL

660 lb (300 kg)

30 mL

770 lb (350 kg)

35 mL

880 lb (400 kg)

40 mL

990 lb (450 kg)

45 mL

1100 lb (500 kg)

50 mL

*Applicator Guns may be purchased from your local veterinarian.

Mode Of Action

Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.

This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.


Studies conducted in the U.S.A. have demonstrated the safety margin for ivermectin. Based on plasma levels, the topically applied formulation is expected to be at least as well tolerated by breeding animals as is the subcutaneous formulation which had no effect on breeding performance.

RESIDUE INFORMATION: Cattle must not be treated within 48 days of slaughter for human consumption. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.


This product should not be applied to self or others because it may be irritating to human skin and eyes and absorbed through the skin. To minimize accidental skin contact, the user should wear a long-sleeved shirt and rubber gloves. If accidental skin contact occurs, wash immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water and seek medical attention.

Keep this and all drugs out of the reach of children.

The Material Safety Data Sheet (MSDS) contains more detailed occupational safety information.



Store between 15° and 30°C (59° and 86°F).

Store away from excessive heat (104°F/40°C) and protect from light.

Use only in well-ventilated areas or outdoors.

Close container tightly when not in use.

Cattle should not be treated when hair or hide is wet since reduced efficacy may be experienced.

Do not use when rain is expected to wet cattle within six hours after treatment.

This product is for application to skin surface only. Do not give orally or parenterally.

Cloudiness in the formulation may occur when ProMectin® B (ivermectin) Pour-On is stored at temperatures below 32°F. Allowing to warm at room temperature will restore the normal appearance without affecting efficacy.

Antiparasitic activity of ivermectin will be impaired if the formulation is applied to areas of the skin with mange scabs or lesions, or with dermatoses or adherent materials, e.g., caked mud or manure.

Ivermectin has been associated with adverse reactions in sensitive dogs; therefore, ProMectin® B (ivermectin) Pour-On is not recommended for use in species other than cattle.

When To Treat Cattle With Grubs

ProMectin® B (ivermectin) Pour-On effectively controls all stages of cattle grubs. However, proper timing of treatment is important. For the most effective results, cattle should be treated as soon as possible after the end of the heel fly (warble fly) season. While this is not peculiar to ivermectin, destruction of Hypoderma larvae (cattle grubs) at the period when these grubs are in vital areas may cause undesirable host-parasite reactions. Killing Hypoderma lineatum when it is in the esophageal tissues may cause bloat; killing H. bovis when it is in the vertebral canal may cause staggering or paralysis. Cattle should be treated either before or after these stages of grub development.

Cattle treated with ProMectin® B (ivermectin) Pour-On at the end of the fly season may be re-treated with ProMectin® B (ivermectin) during the winter without danger of grub-related reactions. For further information and advice on a planned parasite control program, consult your veterinarian.

Environmental Safety

Studies indicate that when ivermectin comes in contact with the soil, it readily and tightly binds to the soil and becomes inactive over time. Free ivermectin may adversely affect fish or certain aquatic organisms. Do not permit cattle to enter lakes, streams or ponds for at least 6 hours after treatment. Do not contaminate water by direct application or by the improper disposal of drug containers. Dispose of containers in an approved landfill or by incineration.

As with other avermectins, ivermectin is excreted in the dung of treated animals and can inhibit the reproduction and growth of pest and beneficial insects that use dung as a source of food and for reproduction. The magnitude and duration of such effects are species and life-cycle specific. When used according to label directions, the product is not expected to have an adverse impact on populations of dung-dependent insects.

Package Information

ProMectin® B (ivermectin) Pour-On is available in a 250 mL (8.5 fl oz) bottle and a 5 L (169 fl oz) backpack.



ProMectin® is a registered trademark of VEDCO, Inc.

Manufactured For: Vedco, Inc., St. Joseph, MO 64507




250 mL (8.5 fl oz)


500018 Rev. 7-00

5 L (169 fl oz)


500018 C-Rev0706

CPN: 10942274

Telephone:   816-238-8840
Toll-Free:   888-708-3326 (888-70VEDCO)
Fax:   816-238-1837
Every effort has been made to ensure the accuracy of the ProMectin B Pour-On For Cattle information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2020 Animalytix LLC. Updated: 2020-10-21