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Denagard Liquid Concentrate 12.5%

This page contains information on Denagard Liquid Concentrate 12.5% for veterinary use.
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  • Denagard Liquid Concentrate 12.5% Indications
  • Warnings and cautions for Denagard Liquid Concentrate 12.5%
  • Direction and dosage information for Denagard Liquid Concentrate 12.5%

Denagard Liquid Concentrate 12.5%

This treatment applies to the following species:
Company: Elanco (Farm Animal)

(tiamulin hydrogen fumarate)

12.5% Tiamulin hydrogen fumarate

NADA 140-916, Approved by FDA

Description

Denagard (tiamulin) Liquid Concentrate is a solution containing 12.5% tiamulin hydrogen fumarate (w/v) in an aqueous solution. The active ingredient, tiamulin, chemically is 14-desoxy-14-[(2-diethylaminoethyl) mercaptoacetoxy] mutilin hydrogen fumarate, a semi-synthetic diterpene antibiotic. Denagard Liquid Concentrate is for use only in preparing medicated drinking water for swine.

Actions: Tiamulin is active against Brachyspira (formerly Serpulina or Treponema) hyodysenteriae and Actinobacillus pleuropneumoniae. It is readily absorbed from the gut and can be found in the blood within 30 minutes after dosing.

Denagard Liquid Concentrate 12.5% Indications

Denagard (tiamulin), when administered in the drinking water for five consecutive days, is an effective antibiotic for the treatment of swine dysentery associated with Brachyspira (formerly Serpulina or Treponema) hyodysenteriae susceptible to tiamulin at a dose level of 3.5 mg tiamulin hydrogen fumarate per pound of body weight daily and for treatment of swine pneumonia due to Actinobacillus pleuropneumoniae susceptible to tiamulin when given at 10.5 mg tiamulin hydrogen fumarate per pound of body weight daily.

Contraindications

Swine being treated with Denagard (tiamulin) should not have access to feeds containing polyether ionophores (e.g., monensin, lasalocid, narasin, salinomycin and semduramicin) as adverse reactions may occur.

Warning

Keep out of reach of children. Avoid direct contact with the skin. Direct contact with skin or mucous membranes may cause irritation.

Residue Warnings: Withdraw medicated water 3 days before slaughter after treatment at 3.5 mg per pound and 7 days before slaughter following treatment at 10.5 mg per pound body weight.

Active Ingredient

The 1 L bottle contains 4.33 oz (125.0 g) tiamulin hydrogen fumarate in solution. The 5 L bottle contains 21.65 oz (625.0 g) tiamulin hydrogen fumarate in solution.

Denagard Liquid Concentrate 12.5% Caution

For use in drinking water of swine only. Prepare fresh medicated water daily. The effects of tiamulin on swine reproductive performance, pregnancy and lactation have not been determined. For animal use only - not for use in humans.

Adverse Reactions

Overdoses of Denagard have sometimes produced transitory salivation, vomiting and an apparent calming effect on the pig. If signs of toxicity occur, discontinue use of medicated water and replace with clean, fresh water.

In rare cases, redness of the skin primarily over the ham and underline has been observed during medication. If these signs appear, discontinue use of this drug. Provide ample clean drinking water. Thoroughly rinse (hose down) the housing to remove urine and feces from animal contact surfaces or move the animals to clean pens. If the condition persists, consult your veterinarian.

Studies to evaluate the safety of the water soluble form of tiamulin in breeding swine have not been done.

Use Directions: Do not use undiluted. The 1 L bottle contains 125,000 mg tiamulin hydrogen fumarate for use in preparing medicated drinking water for swine. The 5L bottle contains 625,000 mg tiamulin hydrogen fumarate for use in preparing medicated drinking water for swine.

The concentration of tiamulin in the drinking water must be adjusted to compensate for variation in water consumption due to weight or size of the pig, environmental temperature and other factors. It is important that pigs receive the proper drug dose, 3.5 mg tiamulin hydrogen fumarate per pound for swine dysentery or 10.5 mg tiamulin hydrogen fumarate per pound for swine pneumonia, each day for 5 consecutive days.

Directions For Preparing Denagard Medicated Solutions

Determine the amount of Denagard Liquid Concentrate needed to medicate the desired volume of drinking water at the proper concentration. Carefully measure out this amount, add it to the water and stir to thoroughly mix.

Number of pigs this bottle will treat for ONE day based on water consumption per pig

One Liter

Net tiamulin hydrogen fumarate content:

125,000 mg

Disease to be treated:

Swine Dysentery

Swine Pneumonia

Daily tiamulin hydrogen fumarate required per pound body weight:

3.5 mg

10.5 mg

Required treatment duration:

5 days

5 days

Pig Wt, lb

Water Intake, gal

# of Pigs

# of Pigs

20

0.3 - 0.5

1,786

595

45

0.4 - 1.1

794

264

75

0.7 - 1.5

476

159

125

1.0 - 2.0

286

95

180

1.2 - 3.0

198

66

Suggested final dilution of:

1 bottle (1 Liter)

550 gal

183 gal

3 bottles (3 Liters)

1650 gal

550 gal

1/2 bottle (0.5 Liters)

275 gal

92 gal

Tiamulin hydrogen fumarate concentration

per gallon at suggested final dilution*

227 mg (60 ppm)

681 mg (180 ppm)


Number of pigs this bottle will treat for ONE day based on water consumption per pig

Five Liters

Net tiamulin hydrogen fumarate content:

625,000 mg

Disease to be treated:

Swine Dysentery

Swine Pneumonia

Daily tiamulin hydrogen fumarate required per pound body weight:

3.5 mg

10.5 mg

Required treatment duration:

5 days

5 days

Pig Wt, lb

Water Intake, gal

# of Pigs

# of Pigs

20

0.3 - 0.5

8,930

2,975

45

0.4 - 1.1

3,970

1,325

75

0.7 - 1.5

2,380

795

125

1.0 - 2.0

1,430

475

180

1.2 - 3.0

990

330

Suggested final dilution of:

1 bottle (5 Liters)

2750 gal

917 gal

3 bottles (15 Liters)

8250 gal

2750 gal

1/2 bottle (2.5 Liters)

1375 gal

458 gal

Tiamulin hydrogen fumarate concentration

per gallon at suggested final dilution*

227 mg (60 ppm)

681 mg (180 ppm)

1. Prepare fresh medicated drinking water every day for the 5 day treatment period.

2. Water medicated with Denagard should be the only source of drinking water during the treatment period.

*3. Increase or decrease dilution rate as required to obtain proper daily drug dose.

Directions For Using Denagard

In medicated proportioners: One liter of Denagard Liquid Concentrate mixed with water to make 4.3 gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 227 mg of tiamulin hydrogen fumarate per gallon to 550 gallons of drinking water for treatment of swine dysentery.

Three liters of Denagard Liquid Concentrate mixed with water to make 4.3 gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 681 mg tiamulin hydrogen fumarate per gallon to a total of 550 gallons of drinking water for treatment of swine pneumonia.

Five liters of Denagard Liquid Concentrate mixed with water to make 21.5 gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 227 mg of tiamulin hydrogen fumarate per gallon to 2750 gallons of drinking water for treatment of swine dysentery.

Fifteen liters of Denagard Liquid Concentrate mixed with water to make 21.5 gallons of stock solution and this stock solution metered at one fluid ounce per gallon will provide 681 mg tiamulin hydrogen fumarate per gallon to a total of 2750 gallons of drinking water for treatment of swine pneumonia.

In barrels or tanks: One liter (1000 mL) of Denagard Liquid Concentrate will medicate 550 gallons of drinking water at 227 mg per gallon for treatment of swine dysentery or 183 gallons at 681 mg per gallon for treatment of swine pneumonia at 381 mg per gallon for treatment of swine pneumonia.

Measure Denagard Liquid Concentrate carefully, pour into the proper amount of water and thoroughly mix. The concentration of tiamulin hydrogen fumarate in the stock solution and in the drinking water delivered must be adjusted to compensate for variation in water consumption by pigs due to body weight, environmental and other factors. It is important that the pigs receive the proper drug dose of 3.5 mg of tiamulin hydrogen fumarate per pound of body weight daily for 5 consecutive days for treatment of swine dysentery or a dose of 10.5 mg per pound body weight daily for 5 consecutive days for treatment of swine pneumonia.

Attention: If no response to treatment is obtained within 5 days re-establish the diagnosis. Failure of response may be related to the presence of non-susceptible organisms of other complicating disease conditions. Because of the tendency for the disease to recur on premises with a history of swine dysentery or with swine pneumonia, a control program should be implemented after treatment. Drugs are not substitutes for proper sanitary measures or good management, but should be used in conjunction with such practices.

How supplied:

Container Size

Active Ingredients

1 Liter bottle (33.8 fl oz; 1000 mL)

12.5% (125.0 g) Tiamulin hydrogen fumarate

5 Liter bottle (169 fl oz; 5000 mL)

12.5% (625.0 g) Tiamulin hydrogen fumarate

Protect from direct sunlight. Store at controlled room temperature, 59°-77°F (15°-25°C).

Observe expiration date.

For technical assistance, call Elanco US Inc. at 1-800-428-4441

Restricted Drug (California): Use only as directed

Elanco, Denagard and the diagonal bar are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.

Manufactured for: Elanco US Inc., Greenfield, IN 46140, USA

 

Product

 

One Liter (1.057 Quarts)

(33.8 fl oz; 1000 mL)

607728

YL100139AMX 311546

Five Liter (5.285 Quarts)

(169 fl oz; 5000 mL)

 

YL100140AMA 311545

311545 YL100140AMB

CPN: 1114111.2

ELANCO US, INC.
Distributed by ELANCO ANIMAL HEALTH
2500 INNOVATION WAY, GREENFIELD, IN, 46140
Main Switchboard:   317-433-4800
Customer Service:   317-276-1262
Small Animal Product Customer Service:   888-545-5973
Technical Services:   800-428-4441
Fax:   317-276-2270
Website:   www.elanco.com
Email:   elanco@elanco.com
Every effort has been made to ensure the accuracy of the Denagard Liquid Concentrate 12.5% information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the US product label or package insert.

Copyright © 2019 Animalytix LLC. Updated: 2019-09-30

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