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Cefa-Dri (Canada)

This page contains information on Cefa-Dri for veterinary use.
The information provided typically includes the following:
  • Cefa-Dri Indications
  • Warnings and cautions for Cefa-Dri
  • Direction and dosage information for Cefa-Dri


This treatment applies to the following species:
Company: Boehringer

Cephapirin Benzathine

For intramammary infusion into the dry cow

Veterinary Use Only

DIN 02173255


Cefa-Dri (cephapirin benzathine) for intramammary infusion into the dry cow is a product which provides a wide range of bactericidal activity against gram-positive and gram-negative organisms. It is derived biosynthetically from 7-aminocephalosporanic acid.

Active Ingredient

Each 10 mL disposable syringe contains 300 mg of cephapirin activity in a stable peanut oil gel.


Do not store above 25°C. Do not freeze.

Action: In the non-lactating mammary gland, Cefa-Dri provides bactericidal levels of the active antibiotic, cephapirin, for a prolonged period of time. This prolonged activity is due to the low solubility of the cephapirin benzathine and to the slow release gel base.

Cephapirin is bactericidal to susceptible organisms; it is known to be highly active against Streptococcus agalactiae.

To determine the susceptibility of bacteria to cephapirin in the laboratory, the class disc, Cephalothin Susceptibility Test Discs, 30 mcg, should be used.

Cefa-Dri Indications

For the treatment of mastitis caused by Streptococcus agalactiae in dairy cows during the dry period.

Cefa-Dri has been shown by extensive clinical studies to be efficacious in the treatment of mastitis in dry cows, when caused by Streptococcus agalactiae.

Treatment of the dry cow with Cefa-Dri is indicated in any cow known to harbour any of these organisms in the udder at drying off.

Dosage and directions for use: Cefa-Dri is for use in dry cows only. Infuse each quarter at the time of drying off with a single 10 mL syringe. Use no later than 30 days prior to calving.

Completely milk out all four quarters. The udder and teats should be thoroughly washed with warm water containing a suitable dairy antiseptic and dried, preferably using individual paper towels. Carefully scrub the teat end and orifice with 70% alcohol, using a separate swab for each teat. Allow to dry.

Cefa-Dri (cephapirin benzathine) is packaged with the protective cap.

For partial insertion: Twist off upper portion of the protective cap to expose 3-4 mm of the syringe tip.

For full insertion: Remove protective cap to expose the full length of the syringe tip.

Insert syringe tip into the teat canal and expel the entire contents of syringe into the quarter. Withdraw the syringe and gently massage the quarter to distribute the medication.

Do not infuse contents of the mastitis syringe into the teat canal if the protective cap is broken or damaged.

Cefa-Dri Caution

Cefa-Dri should be administered with caution to subjects which have demonstrated some form of allergy, particularly to penicillin. Such reactions are rare; however, should they occur, consult your veterinarian.

Warnings: For use in dry cows only. Not to be used within 30 days of calving. Milk from treated cows must not be used for food during the first 84 hours after calving. Any animal infused with this product must not be slaughtered for food until 42 days after the latest infusion. Peanut Allergy Warning: This product contains peanut oil. Keep out of reach of children.

Supply: Cefa-Dri (cephapirin benzathine) for intramammary infusion into the dry cow. Cephapirin benzathine equivalent to 300 mg of cephapirin activity per 10 mL syringe.

Carton containing 24 x 10 mL syringes or pail containing 144 x 10 syringes.

Cefa-Dri is a registered trademark of Boehringer Ingelheim Vetmedica, Inc., used under license.

Boehringer Ingelheim (Canada) Ltd., 5180 South Service Road, Burlington, Ontario L7L 5H4



CPN: 1230071.4

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