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Advantage II Small Dog

This treatment applies to the following species:

Company: Elanco US

Once-A-Month Topical Treatment for Fleas and Lice

For Use ONLY on Dogs and Puppies 7 Weeks and Older and Weighing 3-10 lbs.

READ THE ENTIRE LABEL BEFORE EACH USE

For the Prevention and Treatment of Flea and Lice Infestations on Dogs

● Kills fleas, flea eggs, flea larvae and prevents infestations on dogs

● Kills fleas which may serve as intermediate hosts for tapeworms

● Kills fleas on dogs within 12 hours of application

● Treats, prevents and controls chewing lice infestations on dogs

● Waterproof after 24 hours

● Fragrance-free

Active Ingredients

% by Weight

Imidacloprid

9.10%

Pyriproxyfen

0.46%

OTHER INGREDIENTS:

90.44%

TOTAL

100.00%

KEEP OUT OF REACH OF CHILDREN

Advantage II Small Dog Caution

First Aid

If Swallowed:

● Call a poison control center or doctor immediately for treatment advice.

● Have person sip a glass of water if able to swallow.

● Do not induce vomiting unless told to do so by the poison control center or doctor.

● Do not give anything by mouth to an unconscious person.

If in Eyes:

● Hold eye open and rinse slowly and gently with water for 15-20 minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye.

● Call a poison control center or doctor for treatment advice.

If on Skin or Clothing:

● Take off contaminated clothing. Rinse skin immediately with plenty of water for 15 - 20 minutes.

● Call a poison control center or doctor for treatment advice.

Hot Line Number

Have the product container or label with you when calling a poison control center or doctor or going for treatment. For product questions, to report adverse reactions, or for a copy of the Safety Data Sheet (SDS), call Elanco Product & Veterinary Support at 888-545-5973.

Note To Physician

Treat the patient symptomatically.

Precautionary Statements

Hazards To Humans

Advantage II Small Dog Caution

Harmful if swallowed. Harmful if on skin. Causes moderate eye irritation. Avoid contact with eyes, skin and clothing. Wash hands after handling and before eating, drinking, chewing gum, using tobacco, or using the toilet.

Hazards To Domestic Animals

For external use only. Do not use on puppies or dogs under 7 weeks of age or weighing less than 3 lbs. As with any product, consult your veterinarian before using this product on debilitated, aged, pregnant or nursing dogs. Individual sensitivities may occur after using ANY pesticide product for dogs. If signs persist, or become more severe, consult a veterinarian immediately. If your dog is on medication, consult your veterinarian before using this or any other product.

Side Effects

Monitor your dog after application. Side effects may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as vomiting or diarrhea have also been reported. If these or other side effects (such as lethargy) occur, consult your veterinarian or call 888-545-5973.

DO NOT USE ON CATS.

Keep cats away from treated dogs for 24 hours. If applied to a cat or ingested by a cat, contact your veterinarian.

Directions For Use

It is a violation of Federal Law to use this product in a manner inconsistent with its labeling.

RESTRICTIONS:

● FOR EXTERNAL USE ONLY.

● Use only on dogs seven weeks and older and weighing 3-10 lbs.

● DO NOT use on other animals.

● Weigh your dog before applying to ensure you are applying the correct dose for the weight of your dog.

● DO NOT apply more than one tube per treatment.

● DO NOT have contact or allow children to have contact with treated area until completely dry.

● DO NOT allow your dog to ingest this product.

● In multi-dog households DO NOT allow dogs to have contact with each other until the product has dried.

● DO NOT allow children to apply the product.

● Dogs should be dry prior to application and remain dry for 24 hours after application.

HOW TO OPEN

1. Be sure tube is at bottom of pouch.

2. Using scissors, cut the pouch across the top and remove tube.

HOW TO APPLY

1. Use only on dogs 7 weeks and older and weighing 3 - 10 lbs. Do not apply to puppies or dogs weighing less than 3 lbs. Do not use on other animals.

2. Dogs should be dry prior to application and remain dry for 24 hours after application.

3. Remove one pouch from the carton. See “HOW TO OPEN” section.

4. Hold tube in an upright position facing away from you and your dog’s face and eyes. Pull cap off tube.

5. Turn the cap around and place other end of cap back on tube.

6. Twist cap to break seal, then remove cap from tube.

7. The dog should be standing for easy application. Part the hair on the dog’s back between the shoulder blades, until the skin is visible. Place the tip of the tube on the skin and gently squeeze to expel the entire contents directly on the skin. Do not get this product in your dog’s eyes or allow your dog to ingest this product. Do not allow the product to run off the side of the dog.

8. Discard empty tube as described in the Storage and Disposal section.

9. Under normal conditions the product is effective for a month. However, in case of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven (7) days, not to exceed 4 weekly treatments. After flea control is attained, return to a monthly treatment schedule.

Product Information

The successive feeding activity of fleas on dogs frequently elicits a hypersensitivity skin disorder known as flea allergy dermatitis (FAD) or flea bite hypersensitivity. Treatment of dogs with Advantage II Small Dog kills fleas rapidly, within 12 hours, which may reduce the incidence of this condition.

Advantage II Small Dog kills existing fleas on dogs within 12 hours. Reinfesting fleas are killed within 2 hours with protection against further flea infestation lasting for four (4) weeks.

Advantage II Small Dog provides multi-stage flea control effectively breaking flea life-cycle stages.

Advantage II Small Dog kills adult fleas quickly, within 12 hours, inhibits the development of immature flea life stages and prevents them from reaching the biting adult stage.

Advantage II Small Dog kills chewing lice that infest dogs and puppies and prevents further infestations.

Advantage II Small Dog is waterproof 24 hours after application and remains effective following a shampoo treatment, swimming or after exposure to rain or sunlight.

To successfully prevent and control fleas, all dogs must be treated with their own dose of Advantage II Small Dog.

Apply according to label instructions, ensuring that the product is applied to the skin, not on top of the fur.

If your dog wears a decorative collar, it may be helpful to remove the collar before application, so it doesn’t absorb the product.

Remember, your dog needs to be dry at the time Advantage II Small Dog is applied and remains dry 24 hours after application.

Even indoor dogs need protection against fleas because you or other pets in the household may bring fleas into the home.

Fleas in your dog’s environment can re-infest your dog. If you have a flea infestation, consider treating your home and yard with appropriate premise products to protect against fleas.

For optimal control and prevention of fleas on dogs, apply monthly.

Storage And Disposal

Do not contaminate water, food or feed by storage or disposal.

Pesticide Storage: Store in a cool, dry place inaccessible to children and pets.

Pesticide Disposal and Container Handling: NonrefiIlable container.

If empty: Do not reuse or refill this container. Place in trash or offer for recycling if available.

If partly filled: Call your local solid waste agency or 888-545-5973 for disposal instructions. Never place unused product down any indoor or outdoor drain.

Limited Warranty, Disclaimer, And Limitation Of Damages

By using, buying or handling this product, user and/or buyer accepts the following terms. Subject to the inherent risks referred to above, and to the extent consistent with applicable law, Elanco US Inc.’s (“Elanco”) sole and exclusive limited warranty is that this product conforms to the chemical description on the label and is reasonably fit for the purposes stated on the label, when used in accordance with the label under normal use conditions. To the extent consistent with applicable law, the above exclusive express limited warranty is void if the product is used contrary to the label. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, ELANCO MAKES NO OTHER EXPRESS OR IMPLIED WARRANTY. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, ELANCO DISCLAIMS ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OR OTHERWISE, AND DISCLAIMS ANY OTHER EXPRESS WARRANTY. No agent of Elanco is authorized to make any other warranty, except in writing with a specific reference to this warranty. To the extent consistent with applicable law, Elanco shall not be liable whatsoever for special, incidental or consequential damages resulting from the use or handling of this product. To the extent consistent with applicable law, the sole and exclusive remedy of the user and/or buyer for any and all losses, injuries, or damages, regardless of the legal theory, shall not exceed the purchase price paid for the product, or the replacement of product. To the extent the above disclaimer of warranties disclaims implied warranties, it may be limited or ineffective if you are a “consumer” and this product is a “consumer product,” as those terms are defined by the Magnuson Moss Act, 15 U.S.C. § 2301, in which case the duration of any implied warranties is limited to the earlier of either the applicable statute of limitation or repose, and in no case will any implied warranty extend beyond the term of the Exclusive Express Limited Warranty for the product. To the extent consistent with applicable law, some states do not allow the exclusion or limitation of incidental or consequential damages, so the above limitation or exclusion may not apply to you.

Manufactured For:

Elanco US Inc, 450 Elanco Circle, Indianapolis, IN 46221

EPA Reg. No. 11556-128

Advantage, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates.

© 2025 Elanco or its affiliates.

PA513372X_PA513373X_PA513374X_PA513375X

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Net Contents:

 

4 Tubes, each 0.014 fl. oz. (0.4 mL)

4 monthly doses

6 Tubes, each 0.014 fl. oz. (0.4 mL)

6 monthly doses

CPN: 1131098.2

ELANCO US, INC.
450 ELANCO CIRCLE, INDIANAPOLIS, IN, 46221
Customer Service:   317-276-1262
Technical Service:   800-428-4441
Website:   www.elanco.us
Email:   elanco@elanco.com
THIS SERVICE AND DATA ARE PROVIDED "AS IS". DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. See the Terms of Use for further details.

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Copyright © 2026 Animalytix LLC. Updated: 2026-05-28

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