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Generic Name: alfuzosin (al FUE zoe sin)
Brand Names: Uroxatral

What is Uroxatral?

Uroxatral (alfuzosin) is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blocker.

Uroxatral helps relax the muscles in the prostate and bladder neck, making it easier to urinate.

Uroxatral is used to improve urination in men with benign prostatic hyperplasia (enlarged prostate).

Important information

Uroxatral may cause dizziness or fainting. Be careful if you drive or do anything that requires you to be alert. Avoid standing for long periods of time or becoming overheated during exercise and in hot weather. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

You should not take alfuzosin if you have moderate to severe liver disease.

Uroxatral can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using Uroxatral before surgery unless your surgeon tells you to.

There are many other drugs that can interact with alfuzosin. Tell your doctor about all medications you use.

Before taking this medicine

You should not take Uroxatral if you are allergic to alfuzosin, or if you have:

  • moderate to severe liver disease.

Some medicines can interact with alfuzosin and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • imatinib;

  • isoniazid;

  • nefazodone;

  • an antibiotic - clarithromycin, telithromycin;

  • antifungal medicine - itraconazole, ketoconazole, posaconazole, voriconazole;

  • heart medication - nicardipine, quinidine;

  • antiviral medicine to treat hepatitis C or HIV/AIDS - atazanavir, boceprevir, cobicistat, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, telaprevir; or

  • medicines similar to alfuzosin - doxazosin, prazosin, silodosin, tamsulosin, or terazosin.

To make sure Uroxatral is safe for you, tell your doctor if you have:

  • low blood pressure, or a history of low blood pressure caused by taking medications;

  • kidney disease;

  • a personal or family history of long QT syndrome;

  • heart disease, angina (chest pain), high blood pressure;

  • coronary artery disease (hardened arteries);

  • a history of prostate cancer; or

  • a condition for which you take a nitrate medication (such as nitroglycerin).

Uroxatral can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medicine.

Although Uroxatral is not for use in women, this medicine is not expected to harm an unborn baby or a nursing baby. If you are a woman and you take Uroxatral, tell your doctor if you are pregnant or breast-feeding.

Uroxatral is not approved for use by anyone younger than 18 years old.

How should I take Uroxatral?

Take Uroxatral exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Uroxatral is usually taken once daily just after a meal. Do not take Uroxatral on an empty stomach. Take the medicine at the same time each day.

Do not crush, chew, or break an extended-release tablet. Swallow it whole.

Uroxatral lowers blood pressure and may cause dizziness or fainting, especially when you first start taking it. You may feel very dizzy when you first wake up. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

While using this medicine, your blood pressure and prostate will need to be checked often.

Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, or heavy sweating. Call your doctor if you have a prolonged illness that causes diarrhea or vomiting.

Store at room temperature away from moisture, heat, and light.

Uroxatral dosing information

Usual Adult Dose for Benign Prostatic Hyperplasia:

Extended-release tablet: 10 mg orally once a day immediately after the same meal each day

See also: Dosage Information (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Uroxatral?

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol with this medicine can cause side effects.

Uroxatral side effects

Get emergency medical help if you have signs of an allergic reaction to Uroxatral: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • new or worsening chest pain;

  • upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

  • penis erection that is painful or lasts 4 hours or longer.

Common Uroxatral side effects may include:

  • dizziness;

  • headache;

  • feeling tired; or

  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Uroxatral?

Many drugs can interact with alfuzosin, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Uroxatral. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

  • Your pharmacist can provide more information about Uroxatral.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Uroxatral only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 8.02. Revision Date: 2016-01-29, 11:29:42 AM.