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Levodopa: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on June 20, 2023.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Levodopa inhalation is an inhaled levodopa preparation that may be used to decrease symptoms of slowness, stiffness, or rigidity due to declining plasma levodopa levels in patients with Parkinson's Disease (also known as OFF symptoms). Cough and upper respiratory tract infections are the main side effects reported and it may interact with supplements such as iron salts, vitamin B6 (pyridoxine), and multivitamins.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with levodopa inhalation may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with levodopa inhalation. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with levodopa inhalation include:

Avoid drinking alcohol or taking illegal or recreational drugs while taking levodopa inhalation.

Some foods have high levels of vitamin B6, such as fish, avocados, bananas, beef, cabbage, carrots, cauliflower, chicken, hazelnuts, peanuts, pork, sweetcorn, and walnuts. Ask your doctor if you need to limit your intake of these foods.

Do not take levodopa inhalation within 2 weeks of a nonselective monoamine oxidase inhibitor such as phenelzine or tranylcypromine because it may cause extremely high blood pressure.

Note that this list is not all-inclusive and includes only common medications that may interact with levodopa inhalation. You should refer to the prescribing information for levodopa inhalation for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use levodopa only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: June 20, 2023.