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Kyprolis: 7 things you should know

Medically reviewed by Carmen Pope, BPharm. Last updated on Oct 17, 2023.

1. How it works

2. Upsides

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Kyprolis is a chemotherapy agent that may be used to treat multiple myeloma. It is given by infusion either alone or in combination with other medications once or twice weekly by a healthcare professional. Side effects are common and may include fatigue, shortness of breath, fever, or laboratory abnormalities such as thrombocytopenia, decreased lymphocytes, and lower hemoglobin. Serious side effects of Kyprolis include cardiac toxicities, infusion-related reactions, and hemorrhage.

5. Tips

6. Response and effectiveness

7. Interactions

Medicines that interact with Kyprolis may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with Kyprolis. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Kyprolis interacts with over 270 medications; the majority of these interactions are considered major or moderate. Common medications that may interact with Kyprolis include:

Fatal and serious toxicities have been reported when Kyprolis is used in combination with melphalan and prednisone in newly diagnosed transplant-ineligible patients. Avoid the combination.

Note that this list is not all-inclusive and includes only common medications that may interact with Kyprolis. You should refer to the prescribing information for Kyprolis for a complete list of interactions.


Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Kyprolis only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2024 Revision date: October 17, 2023.