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Symfi

Generic Name: efavirenz, lamivudine, and tenofovir (ef AV ir enz, la MIV ue deen, and ten OF oh vir)
Brand Names: Symfi, Symfi Lo

Medically reviewed on Jun 12, 2018

What is Symfi?

See also: Atripla

Symfi contains a combination of efavirenz, lamivudine, and tenofovir. Efavirenz, lamivudine, and tenofovir are antiviral medicines that prevents human immunodeficiency virus human immunodeficiency virus (HIV) from multiplying in your body.

Symfi Lo is used to treat HIV in adults and children who weigh at least 77 pounds (35 kilograms). Symfi is used in patients weighing at least 88 pounds (40 kg). HIV is the virus that can cause acquired immunodeficiency syndrome (AIDS).

Symfi is not a cure for HIV or AIDS.

Important Information

Symfi may cause a serious condition called lactic acidosis, a dangerous build-up of lactic acid in your blood. Call your doctor or get emergency medical help if you have unusual muscle pain, trouble breathing, stomach pain, dizziness, feeling cold, or feeling very weak or tired.

Call your doctor at once if you have swelling or pain in your upper stomach pain, unusual tiredness, loss of appetite, dark urine, clay-colored stools, or yellowing of the skin or eyes.

Symfi may cause serious mental health problems. Get medical help if you have unusual sadness, paranoia, hallucinations, or thoughts about hurting yourself or others.

If you've ever had hepatitis B, it may become active or get worse after you stop using Symfi. You may need frequent liver function tests for several months.

Before taking this medicine

You should not use this Symfi if:

Tell your doctor if you have ever had:

  • liver disease (especially hepatitis B or C); or

  • kidney disease (or if you are on dialysis);

  • mental illness or psychosis;

  • heart problems;

  • long QT syndrome (in you or a family member);

  • drug or alcohol addiction;

  • a seizure; or

  • fractures or other problems with your bones.

Use effective birth control to prevent pregnancy while you are using Symfi and for at least 12 weeks after your last dose. Efavirenz, lamivudine, and tenofovir could harm an unborn baby or cause birth defects. You may need to have a negative pregnancy test before starting this treatment.

Use two forms of birth control to prevent pregnancy, including a barrier form such as a condom or a diaphragm with spermicide.

Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

How should I take Symfi?

Take Symfi exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Symfi is a complete regimen and is not for use with other antiviral medications.

Take Symfi on an empty stomach at bedtime.

You will need frequent medical tests.

Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor.

Store Symfi in the original container at room temperature, away from moisture and heat.

If you've ever had hepatitis B, this virus may become active or get worse in the months after you stop using Symfi. You may need frequent liver function for several months after your last dose.

Symfi dosing information

Usual Adult Dose for HIV Infection:

1 tablet orally once a day

Use: As a complete regimen for the treatment of HIV-1 infection

Usual Pediatric Dose for HIV Infection:

1 tablet orally once a day

Comments:
-Symfi Lo is approved for patients weighing at least 35 kg.
-Symfi is approved for patients weighing at least 40 kg.
-Recommended for pediatric patients who can swallow a solid tablet

Use: As a complete regimen for the treatment of HIV-1 infection

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

Get your prescription refilled before you run out of medicine completely.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Symfi?

Avoid eating or drinking anything that contains sorbitol (an artificial sweetener).

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Symfi side effects

Get emergency medical help if you have signs of an allergic reaction to Symfi (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Mild symptoms of lactic acidosis may worsen over time, and this condition can be fatal. Get emergency medical help if you have: unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired.

Call your doctor at once if you have:

  • severe dizziness or drowsiness, trouble concentrating;

  • fast or pounding heartbeats, shortness of breath, feeling like you might pass out;

  • strange dreams, hallucinations;

  • new or worsening bone pain;

  • pain in your arms, legs, hands, or feet;

  • pancreatitis - severe pain in your upper stomach spreading to your back, nausea and vomiting;

  • unusual thoughts - fear, paranoia, feeling sad or hopeless, thoughts of hurting yourself or others; or

  • liver problems - swelling around your midsection, upper stomach pain, unusual tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Efavirenz, lamivudine, and tenofovir affect your immune system, which may cause certain side effects (even weeks or months after you've taken Symfi). Tell your doctor if you have:

  • signs of a new infection - fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;

  • trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; or

  • swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence.

Common Symfi side effects may include:

  • dizziness;

  • rash; or

  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Symfi?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may interaction with efavirenz, lamivudine, and tenofovir, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Symfi only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about Symfi (efavirenz / lamivudine / tenofovir)

Consumer resources

Other brands: Symfi Lo

Professional resources

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