Medically reviewed by Drugs.com. Last updated on Oct 5, 2021.
Generic name: EFAVIRENZ 600mg, LAMIVUDINE 300mg, TENOFOVIR DISOPROXIL FUMARATE 300mg
Dosage form: tablet, film coated
Testing Prior to Initiation and During Treatment with SYMFI
Prior to initiation of SYMFI, test patients for hepatitis B virus infection [see Warnings and Precautions (5.1)].
It is recommended that serum creatinine, serum phosphorus, estimated creatinine clearance, urine glucose, and urine protein be assessed before initiating SYMFI and during therapy in all patients as clinically appropriate [see Warnings and Precautions (5.4)].
Monitor hepatic function prior to and during treatment with SYMFI [see Warnings and Precautions (5.9)].
Recommended Dosage for Adult and Pediatric Patients Weighing at Least 40 kg
SYMFI is a three-drug fixed-dose combination product containing 600 mg of efavirenz (EFV), 300 mg of lamivudine (3TC), and 300 mg of tenofovir disoproxil fumarate (TDF). The recommended dosage of SYMFI in HIV-1-infected adults and pediatric patients who weigh at least 40 kg, and can swallow a solid tablet, is one tablet taken orally once daily. SYMFI tablets should be taken on an empty stomach, preferably at bedtime. Dosing at bedtime may improve the tolerability of nervous system symptoms [see Warnings and Precautions (5.6) and Adverse Reactions (6.1)].
Not Recommended in Renal Impairment
Because SYMFI is a fixed-dose combination tablet and cannot be dose adjusted, it is not recommended for patients with impaired renal function (creatinine clearance less than 50 mL/min) or patients with end-stage renal disease (ESRD) requiring hemodialysis [see Use in Specific Populations (8.6)].
Frequently asked questions
- What is the difference between HIV treatments Symfi and Symfi Lo?
- What drugs are contained in the HIV treatment Symfi Lo?
More about Symfi (efavirenz / lamivudine / tenofovir)
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- Drug class: antiviral combinations
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- Symfi Lo
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