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Zolinza Side Effects

Generic name: vorinostat

Medically reviewed by Last updated on Aug 4, 2023.

Note: This document contains side effect information about vorinostat. Some dosage forms listed on this page may not apply to the brand name Zolinza.

Applies to vorinostat: oral capsule.

Serious side effects of Zolinza

Along with its needed effects, vorinostat (the active ingredient contained in Zolinza) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vorinostat:

More common

Less common


Other side effects of Zolinza

Some side effects of vorinostat may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

For Healthcare Professionals

Applies to vorinostat: oral capsule.


Very common (10% or more): Diarrhea (45%), nausea (37%), dry mouth (16%), vomiting (12%), constipation (11%)[Ref]


Very common (10% or more): Thrombocytopenia (26%), anemia (13%)

Frequency not reported: Thromboembolism, deep vein thrombosis[Ref]


Very common (10% or more): Alopecia (16%), pruritus (12%)[Ref]

Nervous system

Very common (10% or more): Dysgeusia (23%), chills (11%), headache (10%)[Ref]


Very common (10% or more): Cough (11%), upper respiratory infection (11%)

Common (1% to 10%): Pulmonary embolism[Ref]


Very common (10% or more): Fatigue (45%), pyrexia (11%)[Ref]


Very common (10% or more): Anorexia (23%), weight loss (20%), muscle spasms (15%), blood creatinine increased (12%), peripheral edema (13%)

Common (1% to 10%): Hyperglycemia[Ref]


1. Product Information. Zolinza (vorinostat). Merck & Co., Inc. 2006.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.