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Zinc sulfate Side Effects

Medically reviewed by Last updated on Apr 8, 2023.

Applies to zinc sulfate: oral capsule, oral tablet, oral tablet extended release. Other dosage forms:

Serious side effects of Zinc sulfate

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Other side effects of Zinc sulfate

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to zinc sulfate: compounding powder, intravenous solution, oral capsule, oral tablet.


Gastrointestinal side effects of zinc sulfate when taken in large doses have included diarrhea, abdominal cramps, and vomiting, usually within 3 to 10 hours of dosing. The symptoms go away soon after discontinuation.[Ref]


Respiratory side effects have included losing sense of smell in patients who use nasal sprays containing zinc.[Ref]

Frequently asked questions


1. Office of Dietary Supplements. National Institutes of Health "Dietary supplement fact sheet: zinc." (2012):

2. Office of Dietary Supplements. National Institutes of Health "Dietary supplement fact sheet: zinc." (2012):

3. "Product Information. Zinc Sulfate (zinc sulfate)." American Regent Laboratories Inc (2012):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.