Zenocutuzumab Side Effects
Medically reviewed by Drugs.com. Last updated on Apr 10, 2025.
Applies to zenocutuzumab: intravenous solution.
General adverse events
The most common adverse events were diarrhea, musculoskeletal pain, fatigue, nausea, infusion-related reactions, dyspnea, rash, constipation, vomiting, abdominal pain, and edema. The most common Grade 3 or 4 laboratory abnormalities were increased gamma-glutamyl transpeptidase (GGT), decreased hemoglobin, decreased sodium, decreased platelets, increased AST, increased ALT, increased alkaline phosphatase, decreased magnesium, decreased phosphate, increased activated partial thromboplastin time (aPTT) and increased bilirubin.[Ref]
Hematologic
- Very common (10% or more): Decreased hemoglobin (35%), decreased platelets (26%), hemorrhage (up to 23%), decreased leukocytes (21%)
- Uncommon (0.1% to 1%): Myelodysplastic syndrome[Ref]
Immunologic
- Very common (10% or more): Infusion-related reactions (up to 13%)[Ref]
Infusion-related reactions (IRR) includes chills, IRR, nausea, cough, diarrhea, back pain, body temperature increased, dyspnea, face edema, fatigue, non-cardiac chest pain, oropharyngeal discomfort, paresthesia, pyrexia, and vomiting.[Ref]
Musculoskeletal
- Very common (10% or more): Musculoskeletal pain (up to 28%)
- Common (1% to 10%): Traumatic fracture[Ref]
Metabolic
- Very common (10% or more): Decreased magnesium (up to 28%), increased alkaline phosphatase (up to 31%), decreased sodium (up to 28%), decreased phosphate (26%), decreased potassium (up to 26%), decreased appetite (up to 11%)[Ref]
Psychiatric
Oncologic
- Uncommon (0.1% to 1%): Tumor pain[Ref]
Respiratory
- Very common (10% or more): Dyspnea (18%), cough (15%)
- Common (1% to 10%): Interstitial lung disease/pneumonitis, respiratory failure
- Uncommon (0.1% to 1%): Upper respiratory infection, pneumonia[Ref]
Other
- Very common (10% or more): Fatigue (up to 21%), COVID-19 (up to 18%), edema (up to 13%), pyrexia (up to 10%)
- Uncommon (0.1% to 1%): Urinary tract infection, viral infection, sepsis, cellulitis, acute cholecystitis, lymphadenitis, staphylococcal infection[Ref]
Renal
- Common (1% to 10%): Increased creatinine
- Uncommon (0.1% to 1%): Acute kidney injury[Ref]
Cardiovascular
- Common (1% to 10%): Cardiac failure, Grade 2 LVEF
- Uncommon (0.1% to 1%): Tachycardia, pericardial effusion, cardiovascular fatal event, bradycardia, carotid artery stenosis[Ref]
Dermatologic
- Very common (10% or more): Rash (14%), dry skin (10%)[Ref]
Gastrointestinal
- Very common (10% or more): Diarrhea (up to 36%), nausea (up to 23%), vomiting (up to 23%), abdominal pain (18%), constipation (15%), abdominal distension (13%), stomatitis (up to 10%)
- Uncommon (0.1% to 1%): Ascites, dysphagia, ileus, gastric obstruction[Ref]
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References
1. (2024) "Product Information. Bizengri (zenocutuzumab)." Merus US, Inc
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Further information
Zenocutuzumab side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.