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Zenapax Side Effects

Generic Name: daclizumab

Note: This page contains side effects data for the generic drug daclizumab. It is possible that some of the dosage forms included below may not apply to the brand name Zenapax.

For the Consumer

Applies to daclizumab: subcutaneous solution

As well as its needed effects, daclizumab (the active ingredient contained in Zenapax) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking daclizumab, check with your doctor immediately:

More common:
  • Bladder pain
  • blistering, crusting, irritation, itching, or reddening of the skin
  • bloody or cloudy urine
  • body aches or pain
  • cough or hoarseness
  • cracked, dry, or scaly skin
  • difficult, burning, or painful urination
  • difficulty with breathing
  • discouragement
  • ear congestion
  • feeling sad or empty
  • fever or chills
  • frequent urge to urinate
  • headache
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • painful or difficult urination
  • rash
  • runny nose
  • sneezing
  • sore throat
  • swelling
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • trouble concentrating
  • trouble sleeping
  • unusual tiredness or weakness
Less common:
  • Dark urine
  • general feeling of tiredness or weakness
  • itching skin
  • light-colored stools
  • persistent loss of appetite
  • red, scaling, or crusted skin
  • right upper quadrant tenderness
  • stomach pain, continuing
  • vomiting
  • yellow eyes or skin
  • Thoughts or attempts at killing oneself
  • watery or bloody diarrhea
Incidence not known:
  • Dizziness
  • fast heartbeat
  • hives or welts
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • tightness in the chest

Minor Side Effects

Some daclizumab side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Blemishes on the skin
  • pimples
  • seizures

For Healthcare Professionals

Applies to daclizumab: intravenous solution, subcutaneous solution


Cardiovascular side effects including tachycardia have been reported in at least 5% of patients.[Ref]


Dermatologic side effects including impaired wound healing without infection and acne have been reported in at least 5% of patients. Pruritus, hirsutism, rash, night sweats, and increased sweating have been reported in between 2% and 5% of patients.[Ref]


Gastrointestinal side effects including constipation, nausea, diarrhea, vomiting, abdominal pain, pyrosis, dyspepsia, abdominal distention, and epigastric pain (not food related) have been reported in at least 5% of patients. Flatulence, gastritis, and hemorrhoids have been reported in between 2% and 5% of patients.[Ref]


Genitourinary side effects including oliguria, dysuria, and renal tubular necrosis have been reported in at least 5% of patients. Renal damage, urinary retention, hydronephrosis, urinary tract bleeding, urinary tract disorder, and renal insufficiency have been reported in between 2% and 5% of patients.[Ref]


Hematologic side effects including thrombosis have been reported in at least 5% of patients.[Ref]


It is recommended that medications used in the treatment of severe hypersensitivity reactions be available for immediate use. If a severe hypersensitivity reaction occurs, therapy with daclizumab (the active ingredient contained in Zenapax) should be permanently discontinued.[Ref]

Hypersensitivity side effects including anaphylaxis have been reported both on initial exposure and following reexposure to daclizumab.[Ref]


Respiratory side effects including dyspnea, pulmonary edema, and coughing have been reported in at least 5% of patients. Atelectasis, congestion, pharyngitis, rhinitis, hypoxia, rales, abnormal breath sounds, and pleural effusion have been reported in between 2% and 5% of patients.[Ref]


Psychiatric side effects including depression and anxiety have been reported in between 2% and 5% of patients.[Ref]


Other side effects including lymphocele have been reported in at least 5% of patients.[Ref]


1. "Product Information. Zenapax (daclizumab)." Roche Laboratories, Nutley, NJ.

It is possible that some side effects of Zenapax may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.