Xospata Side Effects
Generic name: gilteritinib
Medically reviewed by Drugs.com. Last updated on May 11, 2024.
Note: This document provides detailed information about Xospata Side Effects associated with gilteritinib. Some dosage forms listed on this page may not apply specifically to the brand name Xospata.
Applies to gilteritinib: oral tablet.
Important warnings
This medicine can cause some serious health issues
Oral route (tablet)
Warning: Differentiation Syndrome. Patients treated with gilteritinib have experienced symptoms of differentiation syndrome, which can be fatal or life-threatening if not treated.
Symptoms may include fever, dyspnea, hypoxia, pulmonary infiltrates, pleural or pericardial effusions, rapid weight gain or peripheral edema, hypotension, or renal dysfunction.
If differentiation syndrome is suspected, initiate corticosteroid therapy and hemodynamic monitoring until symptom resolution.
Serious side effects of Xospata
Along with its needed effects, gilteritinib (the active ingredient contained in Xospata) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking gilteritinib:
More common side effects
- bloody urine
- blurred vision
- chest pain or tightness
- chills
- confusion
- cough
- decreased frequency or amount of urine
- dizziness
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fainting
- fast or irregular heartbeat
- fever
- headache
- increased thirst
- lightheadedness
- loss of appetite
- lower back or side pain
- nausea
- nervousness
- pounding in the ears
- rapid, shallow breathing
- recurrent fainting
- slow heartbeat
- sneezing
- sore throat
- stomach pain
- sweating
- swelling of the face, fingers, or lower legs
- trouble breathing
- unusual tiredness or weakness
- vomiting
- weight gain
Less common side effects
- anxiety
- blue or pale skin
- chest discomfort
- chest pain, possibly moving to the left arm, neck, or shoulder
- difficulty swallowing
- dilated neck veins
- hives, itching, skin rash
- irregular breathing
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- seizures
- unusual drowsiness
- vision problems
Other side effects of Xospata
Some side effects of gilteritinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common side effects
- change in taste
- constipation
- decreased appetite
- diarrhea
- loss of taste
- muscle or joint pain
- swelling or inflammation of the mouth
- trouble sleeping
For healthcare professionals
Applies to gilteritinib: oral tablet.
Hypersensitivity adverse events
- Common (1% to 10%): Anaphylactic reaction[Ref]
Immunologic
Musculoskeletal
- Very common (10% or more): Myalgia/arthralgia (e.g., arthralgia, back pain, bone pain, myalgia, musculoskeletal pain, neck pain, non-cardiac chest pain, pain in extremity) (42%)[Ref]
Metabolic
- Very common (10% or more): Hyperglycemia (86%), hypocalcemia (61%), edema (34%), hyponatremia (32%), decreased appetite (15%)[Ref]
Psychiatric
- Very common (10% or more): Insomnia (14%)[Ref]
Hepatic
- Very common (10% or more): Increased transaminases (aspartate aminotransferase increased, alanine aminotransferase increased, transaminases increased, liver function test increased, hepatic failure, hepatocellular injury, hepatotoxicity) (41%), bilirubin increased (11%)[Ref]
Respiratory
- Very common (10% or more): Dyspnea (34%), pneumonia (30%), cough (25%)[Ref]
Other
- Very common (10% or more): Fatigue/malaise (40%), fever (35%)
- Common (1% to 10%): Differentiation syndrome[Ref]
Nervous system
- Very common (10% or more): Headache (21%), dizziness (20%), dysgeusia (11%)
- Common (1% to 10%): Posterior reversible encephalopathy syndrome (PRES)[Ref]
Renal
- Very common (10% or more): Renal impairment (e.g., acute kidney injury, blood creatinine increased, chronic kidney disease, oliguria, renal disorder, renal
failure, renal impairment, renal injury, renal tubular necrosis) (19%)[Ref]
Cardiovascular
- Very common (10% or more): Hypotension (30%), hypertension (10%)
- Common (1% to 10%): Prolonged QT interval, cardiac failure (e.g., cardiac failure, cardiac failure congestive, cardiomyopathy, cardiomegaly, chronic left ventricular failure, ejection fraction decreased), pericardial effusion, pericarditis[Ref]
Dermatologic
- Very common (10% or more): Rash (30%)[Ref]
Gastrointestinal
- Very common (10% or more): Noninfectious diarrhea (34%), nausea (27%), stomatitis (26%), vomiting (20%), abdominal pain (e.g., abdominal discomfort, abdominal pain, abdominal pain lower, abdominal pain upper, epigastric discomfort, GI pain) (17%)[Ref]
See also:
Venclexta
Venclexta may be used to treat chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma ...
Vidaza
Vidaza is used to treat certain types of bone marrow cancers and blood cell disorders. Learn about ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Tibsovo
Tibsovo (ivosidenib) is a once-daily oral medication that targets a specific gene mutation called ...
Daunorubicin
Daunorubicin systemic is used for acute lymphocytic leukemia, acute myeloid leukemia, acute ...
Revumenib
Revumenib systemic is used for acute lymphoblastic leukemia, acute myeloid leukemia, leukemia
Ivosidenib
Ivosidenib systemic is used for acute myeloid leukemia, biliary tract tumor, myelodysplastic syndrome
Azacitidine
Azacitidine systemic is used for acute myeloid leukemia, myelodysplastic syndrome
Cytarabine
Cytarabine systemic is used for acute myeloid leukemia, acute nonlymphocytic leukemia, chronic ...
Vincristine
Vincristine systemic is used for acute lymphocytic leukemia, acute myeloid leukemia, anaplastic ...
References
1. (2018) "Product Information. Xospata (gilteritinib)." Astellas Pharma US, Inc
Frequently asked questions
More about Xospata (gilteritinib)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Reviews (1)
- Drug images
- Dosage information
- During pregnancy
- FDA approval history
- Drug class: multikinase inhibitors
- Breastfeeding
- En español
Patient resources
Professional resources
Related treatment guides
Further information
Xospata side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.
