Xospata Dosage
Generic name: GILTERITINIB FUMARATE 40mg
Dosage form: tablet
Drug class: Multikinase inhibitors
Medically reviewed by Drugs.com. Last updated on Apr 21, 2025.
Patient Selection
Select patients for the treatment of AML with XOSPATA based on the presence of FLT3 mutations in the blood or bone marrow.
Posterior Reversible Encephalopathy Syndrome
- •
- Discontinue XOSPATA.
QTc interval greater than 500 msec
- •
- Interrupt XOSPATA.
- •
- Resume XOSPATA at 80 mg when QTc interval returns to within 30 msec of baseline or less than or equal to 480 msec.
QTc interval increased by >30 msec on ECG on day 8 of cycle 1
- •
- Confirm with ECG on day 9.
- •
- If confirmed, consider dose reduction to 80 mg.
Pancreatitis
- •
- Interrupt XOSPATA until pancreatitis is resolved.
- •
- Resume XOSPATA at 80 mg.
Other Grade 3* or higher toxicity considered related to treatment.
- •
- Interrupt XOSPATA until toxicity resolves or improves to Grade 1*.
- •
- Resume XOSPATA at 80 mg.
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Further information
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