Xerava Side Effects
Generic name: eravacycline
Medically reviewed by Drugs.com. Last updated on Mar 16, 2022.
Note: This document contains side effect information about eravacycline. Some of the dosage forms listed on this page may not apply to the brand name Xerava.
For the Consumer
Applies to eravacycline: intravenous powder for solution
Side effects requiring immediate medical attention
Along with its needed effects, eravacycline (the active ingredient contained in Xerava) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking eravacycline:
Less common
- Bleeding wound
- blurred vision
- confusion
- diarrhea
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- red, tender, or oozing skin at the incision site
- sweating
- unusual tiredness or weakness
Rare
- Black, tarry, stools
- bloating
- chest pain
- chills
- constipation
- cough
- dark urine
- difficult or labored breathing
- fast, irregular, pounding, or racing heartbeat or pulse
- fever
- hives, itching, skin rash
- hoarseness
- indigestion
- irritation
- joint pain, stiffness or swelling
- loss of appetite
- lower back or side pain
- mood or mental changes
- muscle cramps in the hands, arms, feet, legs, or face
- nausea
- numbness and tingling around the mouth, fingertips, or feet
- painful or difficult urination
- pains in the stomach, side, or abdomen, possibly radiating to the back
- pale skin
- redness of the skin
- seizures
- sore throat
- stomach cramps
- swelling of the eyelids, face, lips, hands, or feet
- tightness in the chest
- tremor
- troubled breathing or swallowing
- ulcers, sores, or white spots in the mouth
- unusual bleeding or bruising
- vomiting
- yellow eyes or skin
Side effects not requiring immediate medical attention
Some side effects of eravacycline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
- Dry, red, hot, or irritated skin
Rare
- Anxiety
- change in taste
- discouragement
- feeling sad or empty
- loss of interest or pleasure
- loss of taste
- trouble concentrating
- trouble sleeping
For Healthcare Professionals
Applies to eravacycline: intravenous powder for injection
General
The most common side effects were infusion site reactions, nausea, and vomiting. This drug was discontinued due to side effects in 2% of patients (compared to 2% for comparator); discontinuation was most often due to gastrointestinal disorders.[Ref]
Local
Common (1% to 10%): Infusion site reactions (included catheter/vessel puncture site pain, infusion site extravasation, infusion site hypoesthesia, infusion/injection site phlebitis, infusion site thrombosis, injection site/vessel puncture site erythema, phlebitis, superficial phlebitis, thrombophlebitis, vessel puncture site swelling)[Ref]
Gastrointestinal
Common (1% to 10%): Nausea, vomiting, diarrhea
Frequency not reported: Acute pancreatitis, pancreatic necrosis, increased amylase, increased lipase[Ref]
Cardiovascular
Common (1% to 10%): Hypotension
Frequency not reported: Palpitations[Ref]
Other
Common (1% to 10%): Wound dehiscence
Frequency not reported: Chest pain[Ref]
Dermatologic
Frequency not reported: Rash, hyperhidrosis[Ref]
Hematologic
Frequency not reported: Prolonged activated partial thromboplastin time, decreased WBC count, neutropenia[Ref]
Hepatic
Frequency not reported: Increased ALT, increased GGT[Ref]
Hypersensitivity
Frequency not reported: Hypersensitivity[Ref]
Metabolic
Frequency not reported: Hypocalcemia[Ref]
Nervous system
Frequency not reported: Dizziness, dysgeusia[Ref]
Psychiatric
Frequency not reported: Anxiety, insomnia, depression[Ref]
Renal
Frequency not reported: Decreased renal clearance of creatinine[Ref]
Respiratory
Frequency not reported: Pleural effusion, dyspnea[Ref]
Frequently asked questions
More about Xerava (eravacycline)
- Drug interactions
- Dosage information
- During pregnancy or Breastfeeding
- Pricing & coupons
- En español
- Drug class: tetracyclines
- FDA approval history
Patient resources
Professional resources
Related treatment guides
References
1. "Product Information. Xerava (eravacycline)." Tetraphase Pharmaceuticals, Inc (2018):
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.