Xerava Side Effects

Generic name: eravacycline

Medically reviewed by Drugs.com. Last updated on Feb 28, 2025.

Note: This document provides detailed information about Xerava Side Effects associated with eravacycline. Some dosage forms listed on this page may not apply specifically to the brand name Xerava.

Applies to eravacycline: intravenous powder for solution.

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine to make sure it is working properly. Blood tests may be needed to check for unwanted effects.

Tell your doctor if you are pregnant or planning to get pregnant. You should not receive this medicine during the second or third part of a pregnancy.

This medicine may cause permanent discoloration of the teeth and slow down the growth of bones in children younger than 8 years of age. Talk with your doctor if you have concerns.

Eravacycline may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop receiving this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Avoid overexposing your skin to sunlight. Always use sunscreen or sun blocking lotions and wear protective clothing and hats while you are receiving this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Common side effects of Xerava

Some side effects of eravacycline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Xerava

Along with its needed effects, eravacycline (the active ingredient contained in Xerava) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking eravacycline:

See also:

For healthcare professionals

Applies to eravacycline: intravenous powder for injection.

General adverse events

The most common side effects were infusion site reactions, nausea, and vomiting. This drug was discontinued due to side effects in 2% of patients (compared to 2% for comparator); discontinuation was most often due to gastrointestinal disorders.^[Ref]

Cardiovascular

• Common (1% to 10%): Hypotension, thrombophlebitis (includes thrombophlebitis, infusion site thrombosis), phlebitis (includes phlebitis, infusion site phlebitis, superficial phlebitis, injection site phlebitis)
• Frequency not reported: Palpitations

Dermatologic

• Uncommon (0.1% to 1%): Rash, hyperhidrosis

Tetracycline class:

• Frequency not reported: Photosensitivity

Gastrointestinal

• Common (1% to 10%): Nausea, vomiting, diarrhea
• Uncommon (0.1% to 1%): Pancreatitis
• Frequency not reported: Acute pancreatitis, pancreatic necrosis, increased amylase, increased lipase

Antibiotic class:

• Uncommon (0.1% to 1%): Treatment-related diarrhea
• Frequency not reported: Pseudomembranous colitis

Hematologic

• Frequency not reported: Prolonged activated partial thromboplastin time, decreased WBC count, neutropenia

Hepatic

• Uncommon (0.1% to 1%): Increased ALT, increased AST, hyperbilirubinemia
• Frequency not reported: Increased GGT

Hypersensitivity

• Uncommon (0.1% to 1%): Hypersensitivity

Local

• Common (1% to 10%): Infusion site reactions (includes catheter/vessel puncture site pain, infusion site extravasation, infusion site hypoesthesia, infusion/injection site phlebitis, infusion site thrombosis, injection site/vessel puncture site erythema, phlebitis, superficial phlebitis, thrombophlebitis, vessel puncture site swelling, injection site pain/discomfort, injection site swelling/inflammation), infusion site phlebitis
• Uncommon (0.1% to 1%): Infusion site thrombosis, vessel puncture site erythema, infusion site hypoesthesia

Metabolic

• Frequency not reported: Hypocalcemia

Nervous system

• Uncommon (0.1% to 1%): Dizziness, headache
• Frequency not reported: Dysgeusia

Tetracycline class:

• Frequency not reported: Pseudotumor cerebri

Other

• Common (1% to 10%): Wound dehiscence
• Frequency not reported: Chest pain

Antibiotic class:

• Frequency not reported: Overgrowth of nonsusceptible organisms (including fungi)

Tetracycline class:

• Frequency not reported: Antianabolic action (leading to increased BUN, azotemia, acidosis, hyperphosphatemia)

Psychiatric

• Frequency not reported: Anxiety, insomnia, depression

Renal

• Frequency not reported: Decreased renal clearance of creatinine

Respiratory

• Frequency not reported: Pleural effusion, dyspnea

Frequently asked questions

• What type of drug is Xerava?
• What are the strongest antibiotics available?

Further information

Xerava side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer