Skip to main content

Vyzulta Side Effects

Generic name: latanoprostene bunod ophthalmic

Medically reviewed by Last updated on Sep 24, 2023.

Note: This document contains side effect information about latanoprostene bunod ophthalmic. Some dosage forms listed on this page may not apply to the brand name Vyzulta.

Applies to latanoprostene bunod ophthalmic: ophthalmic solution.

Serious side effects of Vyzulta

Along with its needed effects, latanoprostene bunod ophthalmic (the active ingredient contained in Vyzulta) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking latanoprostene bunod ophthalmic:

More common

  • Redness of the white part of the eyes or the inside of the eyelids

Less common

  • Eye irritation


  • Painful irritation of the clear front part of the eye swelling of the eye and the lining of the eyelid

Incidence not known

  • Blurred vision or other change in vision
  • decreased vision
  • eye pain
  • redness of the eye
  • sensitivity of the eye to light
  • tearing

Other side effects of Vyzulta

Some side effects of latanoprostene bunod ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


  • Feeling of having something in the eye

Incidence not known

  • Increased brown color in the colored part of the eye longer, thicker, and darker eyelashes

For Healthcare Professionals

Applies to latanoprostene bunod ophthalmic: ophthalmic solution.


The most frequently reported side effects were conjunctival hyperemia, eye irritation, eye pain, and instillation site pain.[Ref]


Common (1% to 10%): Conjunctival hyperemia, eye irritation, eye pain, instillation site pain

Frequency not reported: Foreign body sensation, punctate keratitis, vision blurred, conjunctival edema, conjunctival irritation[Ref]

About 0.6% of patients discontinued therapy due to ocular adverse reactions including ocular hyperemia, conjunctival irritation, eye irritation, eye pain, conjunctival edema, vision blurred, punctate keratitis, and foreign body sensation.[Ref]


1. Product Information. Vyzulta (latanoprostene bunod ophthalmic). Bausch and Lomb Americas, Inc. 2017.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.