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Vectibix Side Effects

Generic Name: panitumumab

Note: This document contains side effect information about panitumumab. Some of the dosage forms listed on this page may not apply to the brand name Vectibix.

For the Consumer

Applies to panitumumab: intravenous solution

Along with its needed effects, panitumumab (the active ingredient contained in Vectibix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking panitumumab:

More common
  • Anxiety
  • bloating or swelling of the face, arms, hands, lower legs, ankles, or feet
  • chest pain
  • chills
  • confusion
  • constipation
  • convulsions
  • cough
  • decreased urination
  • deep cracks, grooves, or lines in the skin
  • diarrhea
  • difficulty with swallowing
  • discoloration of the fingernails or toenails
  • drowsiness
  • dry mouth, lips, or skin
  • fainting
  • fast or irregular heartbeat
  • fever
  • flushing or redness of the skin
  • increased thirst
  • itching, pain, and swelling of the eyelid
  • itching, skin rash
  • loosening of the fingernails
  • loss of appetite
  • muscle pain or cramps
  • muscle spasms or twitching
  • nausea
  • rapid weight gain
  • rapid, shallow breathing
  • redness or soreness around the fingernails
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • stomach pain
  • sunken eyes
  • swelling or inflammation of the mouth
  • tearing of the eyes
  • tingling of the hands or feet
  • trembling
  • troubled breathing
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • unusually warm skin
  • vomiting
Less common
  • Blurred vision
  • burning, dry, or itching eyes
  • discharge from the eyes or excessive tearing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • facial swelling
  • headache
  • hives
  • noisy breathing
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • sweating
  • swelling of the eye, eyelid, or inner lining of the eyelid
  • tightness in the chest
  • Chest discomfort
  • painful breathing
  • quick, shallow breathing
  • slight fever
Incidence not known
  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, or warmth at the injection site
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

For Healthcare Professionals

Applies to panitumumab: intravenous solution


Very common (10% or more): Erythema (66%), pruritus (58%), acneiform dermatitis (57%), rash (22%), skin fissures (20%), exfoliative rash (18%), alopecia (15%)
Common (1% to 10%): Dry skin, nail disorder, skin exfoliation, skin ulcer, pustular rash, popular rash, Palmar-plantar erythrodysesthesia syndrome
Postmarketing reports: Skin necrosis, life threatening and fatal bullous mucocutaneous disease[Ref]


When used in combination with irinotecan, the incidence and severity of diarrhea is increased. In a study of 19 patients who received panitumumab (the active ingredient contained in Vectibix) in combination with irinotecan, 5-fluorouracil, and leucovorin, the incidence of grade 3 or 4 diarrhea was 58% and was fatal in one patient. The combination of panitumumab with leucovorin is not recommended.[Ref]

Very common (10% or more): Abdominal pain (25%), nausea (23%), diarrhea (21%), constipation (21%), vomiting (19%)
Common (1% to 10%): Stomatitis, mucosal inflammation, dry mouth[Ref]


Very common (10% or more): Anorexia (36%), hypomagnesemia (30%), hypokalemia (21%), weight loss (18%)
Common (1% to 10%): Dehydration
Frequency not reported: Hypocalcemia[Ref]

Median magnesium levels decreased by 0.1 mmol/L. Hypomagnesemia (grade 3 or 4) requiring oral or IV electrolyte repletion occurred in 2% of patients. Hypomagnesemia occurred 6 weeks or longer after the initiation of panitumumab. In some patients, hypomagnesemia was associated with hypocalcemia. Patient's electrolytes should be monitored during and for eight weeks after the completion of panitumumab therapy. Patients should be periodically monitored for hypomagnesemia and accompanying hypocalcemia during the eight weeks after the completion of panitumumab therapy.[Ref]


Very common (10% or more): Dyspnea (18%), cough (15%)
Common (1% to 10%): Epistaxis, pulmonary embolism
Uncommon (0.1% to 1%): Pulmonary fibrosis
Frequency not reported: Nasal dryness, interstitial lung disease (including fatal cases), lung infiltrates[Ref]

Panitumumab should be permanently discontinued in patients developing interstitial lung disease, pneumonitis, or lung infiltrates.[Ref]


Common (1% to 10%): Growth of eyelashes, blepharitis, increased lacrimation, ocular hyperemia, dry eye, eye pruritus, eye irritation, conjunctivitis
Uncommon (0.1% to 1%): eyelid irritation, keratitis
Rare (less than 0.1%): Ulcerative keratitis[Ref]


Severe infusion reactions were identified as anaphylactic reaction, bronchospasm, fever, chills, and hypotension. Although fatal infusion reactions have not been reported with panitumumab (the active ingredient contained in Vectibix) fatalities have occurred with other monoclonal antibody products. The infusion should be stopped if a severe infusion reaction occurs. Depending on the severity and/or persistence of the reaction, panitumumab may need to be permanently discontinued.[Ref]

Common (1% to 10%): Hypersensitivity
Rare (less than 0.1%): Anaphylactic reaction, infusion reaction[Ref]


Very common (10% or more): Anemia
Common (1% to 10%): Leukopenia[Ref]


Very common (10% or more): Paronychia (25%)
Common (1% to 10%): Pustular rash, cellulitis, folliculitis, localized infection
Uncommon (0.1% to 1%): Eye infection, eyelid infection
Postmarketing reports: Angioedema[Ref]

Nervous system

Frequency not reported: Headache[Ref]


Very common (10% or more): Fatigue (26%), peripheral edema (12%)
Common (1% to 10%): Mucosal inflammation, pyrexia, chills[Ref]


Frequency not reported: Acute renal failure (in patients who developed diarrhea and dehydration)[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Pharmaceutical Society of Australia "APPGuide online. Australian prescription products guide online. Available from: URL:" ([2006]):

4. "Product Information. Vectibix (panitumumab)." Amgen USA, Thousand Oaks, CA.

Some side effects of Vectibix may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.