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Valchlor Side Effects

Generic Name: mechlorethamine topical

Note: This page contains side effects data for the generic drug mechlorethamine topical. It is possible that some of the dosage forms included below may not apply to the brand name Valchlor.

For the Consumer

Applies to mechlorethamine topical: topical application gel/jelly

As well as its needed effects, mechlorethamine topical (the active ingredient contained in Valchlor) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking mechlorethamine topical, check with your doctor immediately:

More common:
  • Blistering, crusting, irritation, itching, or reddening of the skin
  • cracked, dry, scaly skin
  • pain, swelling, tenderness, or warmth on the skin

Minor Side Effects

Some mechlorethamine topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Darkening of the skin

For Healthcare Professionals

Applies to mechlorethamine topical: topical gel


Very common (10% or more): Dermatitis (56%), pruritus (20%), bacterial skin infection (11%)
Common (1% to 10%): Skin ulceration or blistering (6%), skin hyperpigmentation (5%)[Ref]


Very common (10% or more): Reductions in hemoglobin, neutrophil count, or platelet count (13%)[Ref]


Common (1% to 10%): Non-melanoma skin cancer (4%)[Ref]


1. "Product Information. Valchlor (mechlorethamine topical)." Ceptaris Therapeutics, Malvern, PA.

It is possible that some side effects of Valchlor may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.