Truqap Side Effects
Generic name: capivasertib
Note: This document contains side effect information about capivasertib. Some dosage forms listed on this page may not apply to the brand name Truqap.
Applies to capivasertib: oral tablet.
Warning
Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
Call your doctor at once if you have:
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redness, new or worsening rash, or blisters on the palms of your hands or the soles of your feet;
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severe stomach pain, diarrhea that is watery or bloody;
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high blood sugar--increased urination, dry mouth, fruity breath odor, nausea, vomiting, appetite or weight changes; or
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dehydration--dizziness, confusion, feeling very thirsty, less urination.
Your cancer treatments may change, be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
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nausea, vomiting, or diarrhea;
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abnormal blood tests;
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blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; or
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tiredness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
For Healthcare Professionals
Applies to capivasertib: oral tablet.
General
Most common adverse reactions/laboratory abnormalities occurring in at least 20% of patients included diarrhea, cutaneous adverse reactions, increased random glucose, decreased lymphocytes, decreased hemoglobin, increased fasting glucose, nausea, fatigue, decreased leukocytes, increased triglycerides, decreased neutrophils, increased creatinine, vomiting, and stomatitis.[Ref]
Dermatologic
Very common (10% or more): Cutaneous adverse reactions (up to 56%)
Cutaneous adverse reactions included butterfly rash, dermatitis, allergic dermatitis, dry skin, eczema, erythema multiforme, hand dermatitis, palmar-plantar erythrodysesthesia syndrome, pruritus, rash, erythematous rash, maculo-papular rash, papular rash, skin discoloration, skin fissures, skin reaction, skin ulcer, urticaria, purpura, erythema and drug eruption.
Gastrointestinal
Very common (10% or more): Diarrhea (up to 77%), nausea (up to 35%), stomatitis (up to 25%), vomiting (up to 21%)
Frequency not reported: Dysgeusia, dyspepsia
Hematologic
Very common (10% or more): Decreased lymphocytes (up to 49%), decreased hemoglobin (up to 47%), decreased leukocytes (up to 35%), increased triglycerides (up to 30%), decreased neutrophils (up to 25%), decreased platelets (up to 12%)
Frequency not reported: Anemia
Hepatic
Very common (10% or more): Increased alanine aminotransferase (up to 23%)
Hypersensitivity
Frequency not reported: Hypersensitivity, including anaphylactic reaction
Metabolic
Very common (10% or more): Increased random glucose (up to 58%), increased fasting glucose (up to 37%), hyperglycemia (up to 19%), decreased corrected calcium (up to 19%), decreased appetite (up to 17%), decreased potassium (up to 17%)
Hyperglycemia included increased blood glucose, increased glycosylated hemoglobin, impaired glucose tolerance, diabetes mellitus, and hyperglycemia.
Other
Very common (10% or more): Fatigue (up to 38%)
Frequency not reported: Pyrexia
Renal
Very common (10% or more): Increased creatinine (up to 19%), urinary tract infection (up to 14%), renal injury (up to 11%)
Renal injury includes acute kidney injury, renal failure, renal impairment, decreased glomerular filtration rate, increased creatinine, and proteinuria.
Respiratory
Frequency not reported: Pneumonia
Nervous system
Very common (10% or more): Headache (up to 17%)
More about Truqap (capivasertib)
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References
1. Product Information. Truqap (capivasertib). Astra-Zeneca Pharmaceuticals. 2023.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.