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Trandate Side Effects

Generic Name: labetalol

Note: This document contains side effect information about labetalol. Some of the dosage forms listed on this page may not apply to the brand name Trandate.

For the Consumer

Applies to labetalol: oral tablet

Other dosage forms:

Along with its needed effects, labetalol (the active ingredient contained in Trandate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking labetalol:

Less common
  • Blurred vision or other changes in vision
  • chills
  • cold sweats
  • confusion
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up from lying or sitting position
  • shortness of breath
  • swelling of face, fingers, feet, or lower legs
  • tightness in chest
  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur while taking labetalol:

Symptoms of overdose
  • Chest pain or discomfort
  • lightheadedness, dizziness, or fainting
  • slow or irregular heartbeat
  • sweating
  • unusual tiredness or weakness

Some side effects of labetalol may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Nausea
Less common
  • Acid or sour stomach
  • belching
  • change in taste or bad, unusual, or unpleasant (after) taste
  • decreased interest in sexual intercourse
  • feeling of constant movement of self or surroundings
  • headache
  • heartburn
  • inability to have or keep an erection
  • indigestion
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • not able to ejaculate semen
  • rash
  • sensation of spinning
  • stomach discomfort, upset, or pain
  • stuffy nose
Rare
  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • diarrhea
  • increased sweating
  • vomiting

For Healthcare Professionals

Applies to labetalol: compounding powder, intravenous solution, oral tablet

Cardiovascular

Common (1% to 10%): Edema, postural hypotension
Frequency not reported: Bradycardia, heart block, heart failure, hypotension, ankle edema, increase of an existing intermittent claudication, postural hypotension, cold or cyanotic extremities, Raynaud's phenomenon, paresthesia of the extremities, syncope[Ref]

Dermatologic

Uncommon (0.1% to 1%): Increased sweating
Frequency not reported: Systemic lupus erythematosus, rashes (e.g., generalized maculopapular, lichenoid, urticarial, bullous lichen planus, psoriaform, facial erythema, Peyronie's disease, reversible alopecia)[Ref]

Endocrine

Frequency not reported: Masking of the normal response to hypoglycemia (sweating and tachycardia); this may be important in some patients with diabetes mellitus[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, dyspepsia, vomiting
Uncommon (0.1% to 1%): Diarrhea
Frequency not reported: Epigastric pain[Ref]

Genitourinary

Common (1% to 10%): Ejaculation failure, impotence
Frequency not reported: Difficulty in micturition (including acute urinary bladder retention)[Ref]

Hepatic

Common (1% to 10%): Transient elevations of liver function tests
Frequency not reported: Hepatic necrosis, hepatitis, cholestatic jaundice[Ref]

Hypersensitivity

Rare (less than 0.1%): Hypersensitivity (e.g., rash, urticaria, pruritus, angioedema, dyspnea), anaphylactoid reactions[Ref]

Immunologic

Frequency not reported: Antimitochondrial antibodies[Ref]

Metabolic

Very rare (less than 0.01%): Hyperkalemia[Ref]

Musculoskeletal

Frequency not reported: Muscle cramps, toxic myopathy[Ref]

Nervous system

Very common (10% or more): Dizziness (11%)
Common (1% to 10%): Headache, taste distortion, vertigo, paresthesia, scalp tingling
Uncommon (0.1% to 1%): Drowsiness
Frequency not reported: Tremor[Ref]

Ocular

Common (1% to 10%): Vision abnormality
Frequency not reported: Dry eyes
Postmarketing reports: Intraoperative Floppy Iris Syndrome (IFIS) observed during cataract surgery[Ref]

Respiratory

Common (1% to 10%): Nasal stuffiness, dyspnea
Frequency not reported: Bronchospasm, interstitial lung disease[Ref]

Other

Common (1% to 10%): Fatigue, asthenia
Frequency not reported: Positive antinuclear factor[Ref]

Psychiatric

Frequency not reported: Depressed mood and lethargy, hallucinations, psychoses, confusion, sleep disturbances, nightmares[Ref]

References

1. "Product Information. Labetalol Hydrochloride (labetalol)." Watson Pharmaceuticals, Parsippany, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Some side effects of Trandate may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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