Tofersen Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 4, 2024.

Applies to tofersen: intrathecal solution.

Precautions

It is very important that your doctor check your progress closely while you are receiving this medicine to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

This medicine may cause myelitis (inflammation of the spinal cord) and radiculitis (nerve problem). Check with your doctor right away if you have back numbness, pain, tingling, or weakness.

Check with your doctor right away if you have confusion, headache, severe nausea or vomiting, or vision changes. These may be symptoms of papilledema (eye problem) and increased intracranial pressure.

This medicine may cause aseptic meningitis (inflammation of the brain). Check with your doctor right away if you have fever, headache, nausea, stiff neck or back, or vomiting.

Serious side effects of tofersen

Along with its needed effects, tofersen may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking tofersen:

For healthcare professionals

Applies to tofersen: intrathecal solution.

General adverse events

The most common adverse reactions occurring in 10% of patients or greater included pain, fatigue, arthralgia, increased cerebrospinal fluid white blood cells, and myalgia.^[Ref]

Immunologic

• Very common (10% or more): Anti-drug antibodies (58.4%)^[Ref]

Musculoskeletal

• Very common (10% or more): Arthralgia (14%), myalgia (14%), musculoskeletal stiffness (6%)^[Ref]

Nervous system

• Very common (10% or more): Cerebrospinal fluid white blood cells increased or pleocytosis (14%)
• Common (1% to 10%): Cerebrospinal fluid proteins increased (8%), neuralgia (6%), myelitis and radiculitis (4%), elevated intracranial pressure and/or papilledema (2.7%), aseptic meningitis (1.4%)^[Ref]

Other

• Very common (10% or more): Pain including extremity and back pain (42%), fatigue (17%)
• Frequency not reported: Pyrexia^[Ref]

See also:

Further information

Tofersen side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer