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Sulfamylon Side Effects

Generic Name: mafenide topical

Note: This page contains side effects data for the generic drug mafenide topical. It is possible that some of the dosage forms included below may not apply to the brand name Sulfamylon.

For the Consumer

Applies to mafenide topical: topical cream, topical powder for solution, topical powder for suspension

As well as its needed effects, mafenide topical (the active ingredient contained in Sulfamylon) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking mafenide topical, check with your doctor immediately:

Less common:
  • Itching
  • skin rash or redness
  • swelling of face or skin
  • wheezing or troubled breathing
Rare
  • Bleeding or oozing of skin
  • drowsiness
  • fast, deep breathing
  • nausea
Incidence unknown
  • Black, tarry stools
  • chest pain
  • chills
  • cough or hoarseness
  • dark urine
  • dizziness
  • fever
  • fluid-filled skin blisters
  • light-colored stools
  • lower back or side pain
  • numbness to feet, hands and around mouth
  • painful or difficult urination
  • rapid shallow breathing
  • sensitivity to the sun
  • shortness of breath
  • skin thinness
  • sore throat
  • sores, ulcers, or white spots on lips or in mouth
  • swollen glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin

Minor Side Effects

Some mafenide topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Pain or burning feeling on treated area(s)
Incidence unknown
  • Blisters
  • flushing
  • raised red swellings on the skin, lips, tongue, or in the throat
  • redness of skin
  • skin rash
  • softening of the skin
  • swelling
  • unusually warm skin

For Healthcare Professionals

Applies to mafenide topical: compounding powder, topical cream, topical powder for reconstitution

General

In the clinical setting of severe burns, it is difficult to distinguish between an adverse reaction to this drug and burn sequelae. In a clinical study in pediatric patients with acute burns requiring autografts who received this drug in addition to double antibiotic solution (DAB) wound therapy (neomycin sulfate 40 mg and polymyxin B 200,000 units/liter), the incidence of rash (4.6%) and itching (2.8%) in the group who received this drug was not different from that experienced with DAB dressings alone (5.7% and 1.3%, respectively).[Ref]

Local

Frequency not reported: Pain, burning sensation, rash, pruritus, excoriation, bleeding[Ref]

Dermatologic

Frequency not reported: Erythema, skin maceration, hives, blisters[Ref]

Respiratory

Frequency not reported: Tachypnea, hyperventilation, partial pressure of carbon dioxide decreased[Ref]

Metabolic

Frequency not reported: Metabolic acidosis, serum chloride increased[Ref]

Hematologic

Frequency not reported: Eosinophilia, bone marrow depression, fatal hemolytic anemia, disseminated intravascular coagulation[Ref]

Other

Frequency not reported: Face edema, swelling, porphyria[Ref]

References

1. "Product Information. Sulfamylon (mafenide topical)." Bertek Pharmaceuticals Inc, Sugar Land, TX.

2. "Product Information. Sulfamylon cream (mafenide topical)." Dow Hickam Pharmaceuticals Inc, Sugar Land, TX.

It is possible that some side effects of Sulfamylon may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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