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Seromycin Side Effects

Generic Name: cycloserine

Note: This page contains side effects data for the generic drug cycloserine. It is possible that some of the dosage forms included below may not apply to the brand name Seromycin.

For the Consumer

Applies to cycloserine: oral capsule

As well as its needed effects, cycloserine (the active ingredient contained in Seromycin) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking cycloserine, check with your doctor immediately:

More common:
  • Anxiety
  • confusion
  • dizziness
  • drowsiness
  • increased irritability
  • increased restlessness
  • mental depression
  • muscle twitching or trembling
  • nervousness
  • nightmares
  • other mood or mental changes
  • speech problems
  • thoughts of suicide
Less common:
  • Convulsions (seizures)
  • numbness, tingling, burning pain, or weakness in the hands or feet
  • skin rash

Minor Side Effects

Some cycloserine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Headache

For Healthcare Professionals

Applies to cycloserine: oral capsule

General

Cycloserine (the active ingredient contained in Seromycin) is most frequently associated with neurotoxicity and hypersensitivity.[Ref]

Nervous system

Nervous system side effects may be dose-related (> 500 mg/day) and have included convulsions, drowsiness, somnolence, headache, tremor, dysarthria, vertigo, confusion, disorientation, loss of memory, psychoses, suicidal tendencies, character changes, hyperirritability, aggression, paresis, hyperreflexia, paresthesia, major and localized seizures, and coma.[Ref]

Hematologic

Hematologic side effects have included vitamin B12 deficiency, folic acid deficiency, megaloblastic anemia, and sideroblastic anemia.[Ref]

Hepatic

Hepatic side effects have included elevated serum transaminases, particularly in patients with preexisting liver disease.[Ref]

Hypersensitivity

Hypersensitivity reactions have included skin rash.[Ref]

Cardiovascular

Cardiovascular side effects have included sudden development of congestive heart failure in patients receiving high doses (1 to 1.5 g/day).[Ref]

References

1. "Product Information. Seromycin (cycloserine)." Dura Pharmaceuticals, San Diego, CA.

It is possible that some side effects of Seromycin may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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