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Sensipar Side Effects

Generic name: cinacalcet

Medically reviewed by Last updated on Aug 18, 2023.

Note: This document contains side effect information about cinacalcet. Some dosage forms listed on this page may not apply to the brand name Sensipar.


Common side effects of Sensipar include: decreased plasma testosterone, diarrhea, dizziness, myalgia, nausea, vomiting, and hypoparathyroidism. Other side effects include: dialysis access infection, asthenia, chest pain, hypertension, hypotension, and anorexia. Continue reading for a comprehensive list of adverse effects.

Applies to cinacalcet: oral tablets.

Side effects include:

Dialysis patients with secondary hyperparathyroidism: Nausea, vomiting, diarrhea, myalgia, dyspnea, cough, hypotension, headache, hypocalcemia, muscle spasms, abdominal pain (including upper abdominal pain), dizziness, hyperkalemia, upper respiratory tract infection, dyspepsia, hypertension, asthenia, anorexia/decreased appetite, noncardiac chest pain, access infection, constipation.

Patients with hypercalcemia associated with parathyroid carcinoma or primary hyperparathyroidism: Adverse effects generally similar to those observed in dialysis patients.

For Healthcare Professionals

Applies to cinacalcet: oral tablet.


Very common (10% or more): Hypotension (11.6%)

Common (1% to 10%): Hypertension

Frequency not reported: Worsening heart failure, QT prolongation and ventricular arrhythmia secondary to hypocalcemia[Ref]


Very common (10% or more): Nausea (31%), vomiting (27%), diarrhea (21%), dyspepsia (13%), abdominal pain (10.9%)

Common (1% to 10%): Upper abdominal pain, dyspepsia, anorexia, constipation[Ref]


Common (1% to 10%): Hypersensitivity reactions

Postmarketing reports: Rash, angioedema, urticaria[Ref]


Common (1% to 10%): Access site infection[Ref]


Very common (10% or more): Paresthesia (14 to 29%)

Very rare (less than 0.01%): Leukocytoclastic vasculitis with palpable purpura on both upper and lower extremities[Ref]


Common (1% to 10%): Anemia[Ref]


Very common (10% or more): Hypocalcemia (11.2%)

Common (1% to 10%): Hyperkalemia, dehydration[Ref]


Very common (10% or more): Cough (11.7%), upper respiratory infection (11%)

Common (1% to 10%): Dyspnea[Ref]


Common (1% to 10%): Reduced testosterone levels[Ref]


Very common (10% or more): Myalgia (15%), muscle spasms (11%)

Common (1% to 10%): Limb pain, back pain, fracture, arthralgia, noncardiac chest pain[Ref]

Nervous system

Very common (10% or more): Paresthesia (up to 29%), headache (11.5%), dizziness (10%)

Common (1% to 10%): Fatigue, seizures[Ref]


Common (1% to 10%): Asthenia[Ref]


Common (1% to 10%): Dialysis access site infection[Ref]


1. Product Information. Sensipar (cinacalcet). Amgen USA. 2004.

2. Cerner Multum, Inc. UK Summary of Product Characteristics.

3. Cerner Multum, Inc. Australian Product Information.

4. Giannikopoulos G, Zorzou MP, Stamoulis I, et al. Cinacalcet-induced leukocytoclastic vasculitis. Am J Kidney Dis. 2009;54:e5-e8.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.