Skip to main content

Sensipar Side Effects

Generic name: cinacalcet

Medically reviewed by Last updated on Jan 5, 2022.

Note: This document contains side effect information about cinacalcet. Some of the dosage forms listed on this page may not apply to the brand name Sensipar.

In Summary

Common side effects of Sensipar include: decreased plasma testosterone, diarrhea, dizziness, myalgia, nausea, vomiting, and hypoparathyroidism. Other side effects include: dialysis access infection, asthenia, chest pain, hypertension, hypotension, and anorexia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cinacalcet: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, cinacalcet (the active ingredient contained in Sensipar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cinacalcet:

More common

Less common

  • Convulsions
  • cough or hoarseness
  • fever or chills
  • loss of bladder control
  • lower back or side pain
  • muscle spasm or jerking of all extremities
  • painful or difficult urination
  • sudden loss of consciousness

Incidence not known

  • Abdominal or stomach cramps
  • confusion
  • decreased urine output
  • difficulty with breathing
  • difficulty with moving
  • dilated neck veins
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • extreme fatigue
  • fainting
  • irregular breathing
  • irregular heartbeats
  • joint pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • low bone turnover
  • mood or mental changes
  • muscle aching or cramping
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle pains or stiffness
  • numbness and tingling around the mouth, fingertips, or feet
  • sweating
  • swelling of the face, fingers, feet, or lower legs
  • swollen joints
  • tightness in the chest
  • tremor
  • troubled breathing
  • unusual tiredness or weakness
  • weight gain

Side effects not requiring immediate medical attention

Some side effects of cinacalcet may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Incidence not known

  • Hives or welts, itching, rash
  • redness of the skin

For Healthcare Professionals

Applies to cinacalcet: oral tablet


Very common (10% or more): Hypotension (11.6%)

Common (1% to 10%): Hypertension

Frequency not reported: Worsening heart failure, QT prolongation and ventricular arrhythmia secondary to hypocalcemia[Ref]


Very common (10% or more): Nausea (31%), vomiting (27%), diarrhea (21%), dyspepsia (13%), abdominal pain (10.9%)

Common (1% to 10%): Upper abdominal pain, dyspepsia, anorexia, constipation[Ref]


Common (1% to 10%): Hypersensitivity reactions

Postmarketing reports: Rash, angioedema, urticaria[Ref]


Common (1% to 10%): Access site infection[Ref]


Very common (10% or more): Paresthesia (14 to 29%)

Very rare (less than 0.01%): Leukocytoclastic vasculitis with palpable purpura on both upper and lower extremities[Ref]


Common (1% to 10%): Anemia[Ref]


Very common (10% or more): Hypocalcemia (11.2%)

Common (1% to 10%): Hyperkalemia, dehydration[Ref]


Very common (10% or more): Cough (11.7%), upper respiratory infection (11%)

Common (1% to 10%): Dyspnea[Ref]


Common (1% to 10%): Reduced testosterone levels[Ref]


Very common (10% or more): Myalgia (15%), muscle spasms (11%)

Common (1% to 10%): Limb pain, back pain, fracture, arthralgia, noncardiac chest pain[Ref]

Nervous system

Very common (10% or more): Paresthesia (up to 29%), headache (11.5%), dizziness (10%)

Common (1% to 10%): Fatigue, seizures[Ref]


Common (1% to 10%): Asthenia[Ref]


Common (1% to 10%): Dialysis access site infection[Ref]


1. "Product Information. Sensipar (cinacalcet)." Amgen USA, Thousand Oaks, CA.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

4. Giannikopoulos G, Zorzou MP, Stamoulis I, et al. "Cinacalcet-induced leukocytoclastic vasculitis." Am J Kidney Dis 54 (2009): e5-e8

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.