Rezdiffra Side Effects

Generic name: resmetirom

Medically reviewed by Drugs.com. Last updated on Nov 10, 2024.

Note: This document provides detailed information about Rezdiffra.

Applies to resmetirom: oral tablets Side Effects associated with resmetirom. Some dosage forms listed on this page may not apply specifically to the brand name Rezdiffra.

Applies to resmetirom: oral tablets.

Side effects include:

Most common adverse reactions with resmetirom (the active ingredient contained in Rezdiffra) (reported in ≥5% of patients and more frequently than placebo) are diarrhea, nausea, pruritus, vomiting, constipation, abdominal pain, and dizziness.

For healthcare professionals

Applies to resmetirom: oral tablet.

General adverse events

The most common adverse reactions reported in at least 5% of patients included diarrhea, nausea, pruritus, vomiting, constipation, abdominal pain, and dizziness.^[Ref]

Cardiovascular

• Frequency not reported: Arrythmia, palpitations

Dermatologic

• Very common (10% or more): Pruritus (up to 10%)
• Frequency not reported: Urticaria, rash, erythema

Endocrine

• Very common (10% or more): Decreased prohormone free T4 (up to 17%)

Gastrointestinal

• Very common (10% or more): Diarrhea (up to 33%), nausea (up to 18%)
• Common (1% to 10%): Constipation, vomiting, abdominal pain
• Frequency not reported: Cholelithiasis, acute cholecystitis, obstructive pancreatitis (gallstone), flatulence, abnormal feces, dysgeusia

Genitourinary

• Frequency not reported: Abnormal uterine bleeding

Hepatic

• Very common (10% or more): ALT greater than 3 times the upper limit of normal (3 x ULN; up to 13%), AST greater than 3 x ULN (up to 12%)
• Common (1% to 10%): ALT greater than 5 x ULN, AST greater than 5 x ULN, total bilirubin elevations greater than 2 x ULN
• Frequency not reported: Hepatotoxicity

Hypersensitivity

• Frequency not reported: Hypersensitivity reactions

Metabolic

• Frequency not reported: Hypoglycemia

Musculoskeletal

• Frequency not reported: Tendinopathy

Nervous system

• Common (1% to 10%): Dizziness
• Frequency not reported: Vertigo

Other

• Frequency not reported: Decreased appetite

Psychiatric

• Frequency not reported: Depression

See also:

Further information

Rezdiffra side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer