Regadenoson Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 12, 2025.

Applies to regadenoson: intravenous solution.

Precautions

It is very important that your doctor check your progress very closely while you are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you start having a rash, itching, increased heart rate, lightheadedness or fainting, trouble breathing, trouble swallowing, swelling of your hands, face, mouth, or throat, or chest pain after you receive the medicine.

Heart attack, stroke, and death may occur after receiving this medicine. Make sure your doctor knows if you have any heart problems (eg, unstable angina or cardiovascular instability) before you have a heart stress test. Check with your doctor right away if you have chest pain or discomfort, nausea, pain or discomfort in arms, jaw, back or neck, sweating, or vomiting.

Make sure your doctor knows if you are using dipyridamole (Persantine®) before you receive this medicine. You may need to stop using dipyridamole for at least 2 days before the test, if possible.

Make sure your doctor knows if you are using aminophylline or theophylline (Theo-24®, Uniphyl®) before you receive this medicine. You may need to stop using aminophylline or theophylline for at least 12 hours before the test.

Do not take anything that contains caffeine for at least 12 hours before you receive this medicine. This includes medicines, foods, and beverages with caffeine, such as coffee, tea, and cola drinks.

Serious side effects of regadenoson

Along with its needed effects, regadenoson may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking regadenoson:

Get emergency help immediately if any of the following symptoms of overdose occur while taking regadenoson:

Symptoms of overdose

• dizziness
• feeling of warmth
• increased heart rate
• redness of the face, neck, arms, and occasionally, upper chest

Other side effects of regadenoson

Some side effects of regadenoson may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

For healthcare professionals

Applies to regadenoson: intravenous solution.

General adverse events

The most common adverse reactions were dyspnea, headache, rhythm or conduction abnormalities, flushing, and rhythm abnormalities.^[Ref]

Cardiovascular

• Very common (10% or more): Rhythm or conduction abnormalities (26%), flushing (up to 23%), rhythm abnormalities (20%), ECG ST segment changes (18%), premature ventricular contractions (14%), angina pectoris or ST segment depression (12%)
• Common (1% to 10%): Premature atrial contractions, first degree atrioventricular (AV) block (PR prolongation greater than 220 msec), ventricular conduction abnormalities, decreased systolic blood pressure (greater than 35 mmHg), decreased diastolic blood pressure (greater than 25 mmHg), angina pectoris, AV block, tachycardia, palpitations, other ECG abnormalities including QTc prolongation, hypotension, ST to T depression of 2 mm or more
• Uncommon (0.1% to 1%): Second degree AV block, AV conduction abnormalities other than AV block, cardiac arrest, myocardial infarction, complete AV block, bradycardia, atrial flutter, atrial fibrillation (new-onset, worsening, or recurrent), hypertension, pallor, peripheral coldness, increased systolic blood pressure (50 mmHg or more), increased diastolic blood pressure (30 mmHg or more), ST to T elevation of 1 mm or more, acute coronary syndrome
• Postmarketing reports: Ventricular arrhythmias, supraventricular tachyarrhythmias, asystole, marked hypertension, symptomatic hypotension^[Ref]

Respiratory

• Very common (10% or more): Dyspnea (up to 29%), pre-specified respiratory adverse reaction (up to 19%)
• Common (1% to 10%): Wheezing, throat tightness, throat irritation, cough
• Uncommon (0.1% to 1%): Tachypnea
• Postmarketing reports: Respiratory arrest, respiratory distress, oxygen saturation decreased^[Ref]

Pre-specified respiratory adverse reactions included dyspnea, wheezing, obstructive airway disorder, dyspnea exertional, and tachypnea.^[Ref]

Nervous system

• Very common (10% or more): Headache (27%), dizziness (up to 11%)
• Common (1% to 10%): Dysgeusia, paresthesia, hypoesthesia, severe headache
• Uncommon (0.1% to 1%): Convulsions, syncope, transient ischemic attack, unresponsiveness to stimuli, depressed level of consciousness, tremor, somnolence, tinnitus
• Rare (less than 0.1%): Cerebrovascular accident
• Postmarketing reports: Intracranial hemorrhage^[Ref]

Other

• Very common (10% or more): Chest pain (up to 19%), chest discomfort (13%)
• Common (1% to 10%): Malaise, asthenia
• Uncommon (0.1% to 1%): General body pain^[Ref]

Gastrointestinal

• Very common (10% or more): Gastrointestinal discomfort (15%)
• Common (1% to 10%): Nausea, abdominal discomfort, vomiting, oral discomfort
• Uncommon (0.1% to 1%): Abdominal distention, diarrhea, fecal incontinence
• Postmarketing reports: Abdominal pain^[Ref]

Musculoskeletal

• Common (1% to 10%): Back or neck or jaw pain, pain in extremity, musculoskeletal discomfort
• Uncommon (0.1% to 1%): Arthralgia^[Ref]

Dermatologic

• Common (1% to 10%): Hyperhidrosis
• Uncommon (0.1% to 1%): Angioedema, urticaria, rash, erythema^[Ref]

Ocular

• Uncommon (0.1% to 1%): Vision blurred, eye pain^[Ref]

Psychiatric

• Uncommon (0.1% to 1%): Anxiety, insomnia^[Ref]

Immunologic

• Uncommon (0.1% to 1%): Anaphylaxis^[Ref]

Local

• Uncommon (0.1% to 1%): Pain at injection site^[Ref]

See also:

Further information

Regadenoson side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer