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Regadenoson Side Effects

In Summary

Commonly reported side effects of regadenoson include: bronchoconstriction and dyspnea. Other side effects include: systolic hypotension. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to regadenoson: intravenous solution

As well as its needed effects, regadenoson may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking regadenoson, check with your doctor or nurse immediately:

More common:
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • difficult or labored breathing
  • fast or irregular heartbeat
  • nausea
  • sweating
  • tightness in the chest
Incidence not known:
  • Confusion
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • irregular heartbeat recurrent
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash, hives, or itching skin
  • trembling or shaking of the hands or feet
  • unusual tiredness or weakness

If any of the following symptoms of overdose occur while taking regadenoson, get emergency help immediately:

Symptoms of overdose:
  • Dizziness
  • feeling of warmth
  • increased heart rate
  • redness of the face, neck, arms, and occasionally, upper chest

Minor Side Effects

Some regadenoson side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Headache
Less common:
  • Change in taste
  • loss of taste
  • stomach soreness or discomfort
Incidence not known:
  • Diarrhea
  • difficulty with moving
  • joint pain
  • muscle aching or cramping

For Healthcare Professionals

Applies to regadenoson: intravenous solution


The most common adverse reactions were dyspnea, headache, rhythm or conduction abnormalities, flushing, and rhythm abnormalities.[Ref]


Very common (10% or more): Rhythm or conduction abnormalities (26%), flushing (up to 23%), rhythm abnormalities (20%), ECG ST segment changes (18%), premature ventricular contractions (14%), angina pectoris or ST segment depression (12%)
Common (1% to 10%): Premature atrial contractions, first degree atrioventricular (AV) block (PR prolongation greater than 220 msec), ventricular conduction abnormalities, decreased systolic blood pressure (greater than 35 mmHg), decreased diastolic blood pressure (greater than 25 mmHg), angina pectoris, AV block, tachycardia, palpitations, other ECG abnormalities including QTc prolongation, hypotension, ST to T depression of 2 mm or more
Uncommon (0.1% to 1%): Second degree AV block, AV conduction abnormalities other than AV block, cardiac arrest, myocardial infarction, complete AV block, bradycardia, atrial flutter, atrial fibrillation (new-onset, worsening, or recurrent), hypertension, pallor, peripheral coldness, increased systolic blood pressure (50 mmHg or more), increased diastolic blood pressure (30 mmHg or more), ST to T elevation of 1 mm or more, acute coronary syndrome
Postmarketing reports: Ventricular arrhythmias, supraventricular tachyarrhythmias, asystole, marked hypertension, symptomatic hypotension[Ref]


Pre-specified respiratory adverse reactions included dyspnea, wheezing, obstructive airway disorder, dyspnea exertional, and tachypnea.[Ref]

Very common (10% or more): Dyspnea (up to 29%), pre-specified respiratory adverse reaction (up to 19%)
Common (1% to 10%): Wheezing, throat tightness, throat irritation, cough
Uncommon (0.1% to 1%): Tachypnea
Postmarketing reports: Respiratory arrest, respiratory distress, oxygen saturation decreased[Ref]

Nervous system

Very common (10% or more): Headache (27%), dizziness (up to 11%)
Common (1% to 10%): Dysgeusia, paresthesia, hypoesthesia, severe headache
Uncommon (0.1% to 1%): Convulsions, syncope, transient ischemic attack, unresponsiveness to stimuli, depressed level of consciousness, tremor, somnolence, tinnitus
Rare (less than 0.1%): Cerebrovascular accident
Postmarketing reports: Intracranial hemorrhage[Ref]


Very common (10% or more): Chest pain (up to 19%), chest discomfort (13%)
Common (1% to 10%): Malaise, asthenia
Uncommon (0.1% to 1%): General body pain[Ref]


Very common (10% or more): Gastrointestinal discomfort (15%)
Common (1% to 10%): Nausea, abdominal discomfort, vomiting, oral discomfort
Uncommon (0.1% to 1%): Abdominal distention, diarrhea, fecal incontinence
Postmarketing reports: Abdominal pain[Ref]


Common (1% to 10%): Back or neck or jaw pain, pain in extremity, musculoskeletal discomfort
Uncommon (0.1% to 1%): Arthralgia[Ref]


Common (1% to 10%): Hyperhidrosis
Uncommon (0.1% to 1%): Angioedema, urticaria, rash, erythema[Ref]


Uncommon (0.1% to 1%): Vision blurred, eye pain[Ref]


Uncommon (0.1% to 1%): Anxiety, insomnia[Ref]


Uncommon (0.1% to 1%): Anaphylaxis[Ref]


Uncommon (0.1% to 1%): Pain at injection site[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Lexiscan (regadenoson)." Astellas Pharma US, Inc, Deerfield, IL.

It is possible that some side effects of regadenoson may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.