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Regadenoson Side Effects

In Summary

Commonly reported side effects of regadenoson include: dyspnea and bronchoconstriction. Other side effects include: systolic hypotension. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to regadenoson: intravenous solution

As well as its needed effects, regadenoson may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking regadenoson, check with your doctor or nurse immediately:

More common:
  • Arm, back, or jaw pain
  • chest pain or discomfort
  • difficult or labored breathing
  • fast or irregular heartbeat
  • nausea
  • sweating
  • tightness in the chest
Incidence not known:
  • Confusion
  • difficulty swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • irregular heartbeat recurrent
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rash, hives, or itching skin
  • trembling or shaking of the hands or feet
  • unusual tiredness or weakness

If any of the following symptoms of overdose occur while taking regadenoson, get emergency help immediately:

Symptoms of overdose:
  • Dizziness
  • feeling of warmth
  • increased heart rate
  • redness of the face, neck, arms, and occasionally, upper chest

Severity: Minor

Some regadenoson side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Headache
Less common:
  • Change in taste
  • loss of taste
  • stomach soreness or discomfort
Incidence not known:
  • Diarrhea
  • difficulty with moving
  • joint pain
  • muscle aching or cramping

For Healthcare Professionals

Applies to regadenoson: intravenous solution


Respiratory side effects including dyspnea (28%) have been reported.[Ref]

Nervous system

Nervous system side effects including headache (26%) and dizziness (8%) have been reported.[Ref]


Cardiovascular side effects have included tachycardia (22%), flushing (16%), premature ventricular contractions (14%), chest discomfort (13%), angina or ST segment depression (12%), Chest pain (7%), premature atrial contractions (7%), systolic blood pressure decreased greater than 35 mm Hg (7%), ventricular conduction abnormalities (6%) diastolic blood pressure decreased more than 25 mm Hg (4%), first-degree AV block (PR prolongation greater than 220 msec; 3%), second-degree AV block (less than 1%), AV conduction abnormalities (other than AV blocks; less than 1%).[Ref]


Gastrointestinal side effects including nausea (6%), abdominal discomfort (5%), and dysgeusia (5%) have been reported.[Ref]


General side effects including feeling hot (5%) have been reported.[Ref]


1. "Product Information. Lexiscan (regadenoson)." Astellas Pharma US, Inc, Deerfield, IL.

It is possible that some side effects of regadenoson may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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