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Rapaflo Side Effects

Generic Name: silodosin

Note: This document contains side effect information about silodosin. Some of the dosage forms listed on this page may not apply to the brand name Rapaflo.

In Summary

Common side effects of Rapaflo include: retrograde ejaculation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to silodosin: oral capsule

Along with its needed effects, silodosin (the active ingredient contained in Rapaflo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking silodosin:

Less common
  • Chills
  • cold sweats
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
Incidence not known
  • Abdominal or stomach pain
  • clay-colored stools
  • dark urine
  • fever
  • headache
  • itching
  • loss of appetite
  • nausea
  • pinpoint red or purple spots on the skin
  • rash
  • skin blisters
  • unpleasant breath odor
  • unusual tiredness or weakness
  • vomiting of blood
  • yellow eyes or skin

Some side effects of silodosin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Change or problem with discharge of semen
Less common

For Healthcare Professionals

Applies to silodosin: oral capsule


The most common adverse reaction was retrograde ejaculation.[Ref]


Very common (10% or more): Retrograde ejaculation (28.1%)
Common (1% to 10%): Prostate-specific antigen (PSA) increased
Uncommon (0.1% to 1%): Priapism[Ref]


Common (1% to 10%): Nasopharyngitis, nasal congestion, sinusitis, rhinorrhea
Postmarketing reports: Pharyngeal edema[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache
Uncommon (0.1% to 1%): Syncope[Ref]


Common (1% to 10%): Diarrhea, abdominal pain
Postmarketing reports: Swollen tongue[Ref]


Common (1% to 10%): Orthostatic hypotension[Ref]


Common (1% to 10%): Asthenia[Ref]


Common (1% to 10%): Insomnia[Ref]


Frequency not reported: Intraoperative floppy iris syndrome[Ref]


Postmarketing reports: Toxic skin eruption, purpura, skin rash, pruritus, urticaria[Ref]


Postmarketing reports: Jaundice, hepatic function impaired, transaminases increased[Ref]


Postmarketing reports: Allergic-type reactions[Ref]


1. "Product Information. Rapaflo (silodosin)." Watson Pharmaceuticals, Corona, CA.

Some side effects of Rapaflo may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.