Rapaflo Side Effects

Generic name: silodosin

Medically reviewed by Drugs.com. Last updated on Mar 24, 2025.

Note: This document provides detailed information about Rapaflo Side Effects associated with silodosin. Some dosage forms listed on this page may not apply specifically to the brand name Rapaflo.

Applies to silodosin: oral capsule.

Precautions

It is very important that your doctor check your progress at regular visits for any unwanted effects that may be caused by this medicine.

Do not use this medicine if you are also taking clarithromycin (Biaxin®), ketoconazole (Nizoral®), itraconazole (Sporanox®), or ritonavir (Norvir®). Using these medicines together may cause serious unwanted effects.

Dizziness, lightheadedness, or fainting may occur after you take this medicine, especially when you get up from a lying or sitting position. Getting up slowly may help lessen this problem. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning.

This medicine may cause some people to become dizzy or less alert than they are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Benign prostatic hyperplasia can have the same symptoms as prostate cancer. They may also often occur together. Your doctor may test for the presence of the cancer before you start using this medicine.

Tell your eye doctor (ophthalmologist) that you have used or are using this medicine before cataract surgery or any other eye procedure. This medicine may cause a serious eye problem called Intraoperative Floppy Iris Syndrome (IFIS).

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Common side effects of Rapaflo

Some side effects of silodosin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Serious side effects of Rapaflo

Along with its needed effects, silodosin (the active ingredient contained in Rapaflo) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking silodosin:

For healthcare professionals

Applies to silodosin: oral capsule.

General adverse events

The most common adverse reaction was retrograde ejaculation.^[Ref]

Genitourinary

• Very common (10% or more): Retrograde ejaculation (28.1%)
• Common (1% to 10%): Prostate-specific antigen (PSA) increased
• Uncommon (0.1% to 1%): Priapism^[Ref]

Respiratory

• Common (1% to 10%): Nasopharyngitis, nasal congestion, sinusitis, rhinorrhea
• Postmarketing reports: Pharyngeal edema^[Ref]

Nervous system

• Common (1% to 10%): Dizziness, headache
• Uncommon (0.1% to 1%): Syncope^[Ref]

Gastrointestinal

• Common (1% to 10%): Diarrhea, abdominal pain
• Postmarketing reports: Swollen tongue^[Ref]

Cardiovascular

• Common (1% to 10%): Orthostatic hypotension^[Ref]

Other

• Common (1% to 10%): Asthenia^[Ref]

Psychiatric

• Common (1% to 10%): Insomnia^[Ref]

Ocular

• Frequency not reported: Intraoperative floppy iris syndrome^[Ref]

Dermatologic

• Postmarketing reports: Toxic skin eruption, purpura, skin rash, pruritus, urticaria^[Ref]

Hepatic

• Postmarketing reports: Jaundice, hepatic function impaired, transaminases increased^[Ref]

Immunologic

• Postmarketing reports: Allergic-type reactions^[Ref]

See also:

Further information

Rapaflo side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer