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Rabies vaccine, human diploid cell Side Effects

Applies to rabies vaccine, human diploid cell: intramuscular powder for injection.


You should not receive a booster vaccine if you had a life threatening allergic reaction after the first shot.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

You should not receive a booster vaccine if you had a life-threatening allergic reaction after the first shot.

Keep track of any and all side effects you have after receiving this vaccine. When you receive a booster dose, you will need to tell the doctor if the previous shot caused any side effects.

Becoming infected with rabies is much more dangerous to your health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Call your doctor at once if you have rare but serious side effects, such as:

Common side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to rabies vaccine, human diploid cell: intramuscular powder for injection.


The most common side effects have included local injection site reactions in up to 25% of patients. The most common systemic reactions have included malaise, headache, nausea, muscle aches, and dizziness in up to 20% of patients. Rabies prophylaxis should not be interrupted or discontinued because of local or mild systemic reactions. These reactions usually can be managed with antipyretics and anti-inflammatories.

The risk of developing a potentially fatal rabies infection should be considered before making the decision to discontinue rabies vaccination when severe anaphylactic or neuroparalytic reactions occur. The State Health Department or Centers for Disease Control and Prevention may be consulted for advice on managing serious reactions.[Ref]


Very common (10% or more): Pain, erythema, swelling, or itching at the injection site (25%)

Frequency not reported: Tenderness at the injection site, induration

Postmarketing reports: Injection site hematoma[Ref]


Postmarketing reports: Anaphylactic reaction, serum sickness type reaction, dermatitis allergic skin reactions (pruritus, edema, urticaria, rash)[Ref]

Nervous system

Frequency not reported: Headache, dizziness

Postmarketing reports: Paresthesia, neuropathy, convulsion, encephalitis[Ref]


Frequency not reported: Fever

Postmarketing reports: Asthenia, malaise, shivering[Ref]


Frequency not reported: Muscle aches

Postmarketing reports: Arthralgia[Ref]


Frequency not reported: Nausea, abdominal pain

Postmarketing reports: Vomiting, diarrhea[Ref]


Postmarketing reports: Wheezing, dyspnea[Ref]


Postmarketing reports: Lymphadenopathy[Ref]

More about rabies vaccine, human diploid cell

Patient resources

Other brands

Imovax Rabies

Professional resources

Other brands

Imovax Rabies

Related treatment guides


1. Product Information. Imovax Rabies (rabies vaccine, human diploid cell). sanofi pasteur. 2006.

2. Cerner Multum, Inc. Australian Product Information.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.