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Procrit Side Effects

Generic Name: epoetin alfa

Note: This document contains side effect information about epoetin alfa. Some of the dosage forms listed on this page may not apply to the brand name Procrit.

For the Consumer

Applies to epoetin alfa: injection solution

Along with its needed effects, epoetin alfa (the active ingredient contained in Procrit) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking epoetin alfa:

More common
  • Chest pain
  • fever
  • headache
  • increased blood pressure
  • swelling of the face, fingers, ankles, feet, or lower legs
  • weight gain
Less common
  • Anxiety
  • blurred vision
  • change in skin color
  • change in vision
  • cough
  • dizziness or lightheadedness
  • double vision
  • fainting
  • fast heartbeat
  • migraine headache
  • nausea
  • pain or discomfort in the arms, jaw, back, or neck
  • pain, tenderness, or swelling of the foot or leg
  • pain in the chest, groin, or legs, especially calves of the legs
  • pale skin
  • partial or complete loss of vision in the eye
  • seizures
  • severe headache of sudden onset
  • skin rash or hives
  • slurred speech
  • sore throat
  • sudden and severe inability to speak
  • sudden loss of coordination
  • sweating
  • temporary blindness
  • tenderness, pain, swelling, warmth, or skin discoloration at the injection site
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vision problems
  • vomiting
  • weakness in the arm or leg on one side of the body, sudden and severe

Some side effects of epoetin alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bone or joint pain, muscle aches, chills, shivering, sweating
  • constipation
  • diarrhea
  • general feeling of tiredness or weakness
  • heartburn or belching
  • itching or stinging at the injection site
  • loss of strength or energy
  • muscle pain or weakness
  • skin pain
  • stomach discomfort, upset, pain, or swelling
  • weight loss

For Healthcare Professionals

Applies to epoetin alfa: injectable solution

General

The most common adverse reaction was dose-dependent increase in blood pressure or aggravation of existing hypertension.[Ref]

Gastrointestinal

Very common (10% or more): Nausea (up to 56%), diarrhea (up to 30%), vomiting (up to 28%), stomatitis (10%)
Common (1% to 10%): Dysphagia
Frequency not reported: Vomiting[Ref]

Other

Very common (10% or more): Pyrexia (up to 42%)
Common (1% to 10%): Chills, influenza-like illness, peripheral edema, artificial kidney clotting during dialysis, edema[Ref]

Nervous system

Very common (10% or more): Headache (up to 34%)
Common (1% to 10%): Convulsion, dizziness
Frequency not reported: Cerebrovascular accident, transient ischemic attack[Ref]

Cardiovascular

Very common (10% or more): Hypertension (up to 33%), embolism and thrombosis (up to 15%)
Common (1% to 10%): Deep vein thrombosis, thrombosis
Uncommon (0.1% to 1%): Myocardial infarction
Frequency not reported: Blood pressure increased, aneurysm[Ref]

Respiratory

Very common (10% or more): Cough (up to 26%)
Common (1% to 10%): Respiratory tract congestion, upper respiratory tract infection, pulmonary embolism[Ref]

Dermatologic

Very common (10% or more): Rash (up to 25%), pruritus (up to 21%)
Common (1% to 10%): Urticaria
Uncommon (0.1% to 1%): Erythema
Frequency not reported: Angioedema[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (up to 24%), pain in extremity (up to 15%), myalgia (up to 10%)
Common (1% to 10%): Bone pain, muscle spasm
Frequency not reported: Porphyria[Ref]

Local

Very common (10% or more): Injection site reaction (up to 18%), injection site pain (up to 13%)
Common (1% to 10%): Vascular access thrombosis[Ref]

Metabolic

Very common (10% or more): Hyperkalemia (up to 10%)
Common (1% to 10%): Weight decrease, hyperglycemia, hypokalemia[Ref]

Psychiatric

Common (1% to 10%): Insomnia, depression[Ref]

Hematologic

Common (1% to 10%): Leukopenia
Postmarketing reports: Erythropoietin antibody-mediated pure red cell aplasia, thrombocytopenia[Ref]

Immunologic

Frequency not reported: Anaphylactic reaction, hypersensitivity
Postmarketing reports: Serious allergic reaction[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. Epogen (epoetin alfa)." Amgen, Thousand Oaks, CA.

3. Cerner Multum, Inc. "Australian Product Information." O 0

4. "Product Information. Procrit (epoetin alfa)." Ortho Biotech Inc, Raritan, NJ.

Some side effects of Procrit may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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