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Priftin Side Effects

Generic name: rifapentine

Medically reviewed by Last updated on Mar 14, 2021.

Note: This document contains side effect information about rifapentine. Some of the dosage forms listed on this page may not apply to the brand name Priftin.

In Summary

More frequent side effects include: diarrhea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to rifapentine: oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, rifapentine (the active ingredient contained in Priftin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking rifapentine:

More common

  • Black, tarry stools
  • chills
  • cough
  • coughing up blood
  • fever
  • hoarseness
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • skin rash
  • sore throat
  • trouble breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Bleeding gums
  • blood in the urine or stools
  • burning, dry, or itching eyes
  • excessive tearing of the eye
  • eye pain
  • fast heartbeat
  • general feeling of illness
  • headache
  • hives, itching
  • irritation
  • joint pain, stiffness, or swelling
  • loss of appetite
  • pinpoint red spots on the skin
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • tightness in the chest
  • trouble breathing or swallowing
  • weight loss


  • Anxiety
  • bloating
  • blue or pale skin
  • burning feeling in the chest or stomach
  • burning, tingling, numbness, or pain in the hands, arms, feet, or legs
  • chest pain, possibly moving to the left arm, neck, or shoulder
  • cloudy or dark urine
  • cold sweat
  • collection of blood under the skin
  • confusion
  • constipation
  • deep, dark purple bruise
  • dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fast, pounding, or irregular heartbeat or pulse
  • heartburn
  • indigestion
  • itching in the genital or other skin areas
  • lack or loss of strength
  • light-colored stools
  • muscle pain
  • nausea
  • noisy breathing
  • pain in the lower back or side
  • pain or burning in the throat
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • right upper stomach pain and fullness
  • scaling of the skin
  • seizures
  • stabbing pain
  • stomach upset
  • tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
  • thick, white vaginal discharge with mild or no odor
  • thickening of bronchial secretions
  • thirst
  • vaginal bleeding
  • voice changes
  • vomiting
  • yellow skin or eyes

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • diarrhea
  • red skin lesions, often with a purple center
  • sensitivity of the skin to the sun
  • thinning of the skin

Side effects not requiring immediate medical attention

Some side effects of rifapentine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Increased sweating

Less common


  • Discoloration of the skin
  • drowsiness

For Healthcare Professionals

Applies to rifapentine: oral tablet


The most commonly reported side effects included anemia, lymphopenia, hemoptysis, and neutropenia.[Ref]


Very common (10% or more): Anemia (up to 11.4%), lymphopenia (up to 10.5%)

Common (1% to 10%): Leukocytosis, lymphadenopathy, neutropenia, thrombocytopenia, thrombocytosis

Frequency not reported: Leukopenia, lymphocytosis[Ref]


Common (1% to 10%): Abdominal pain, diarrhea, dyspepsia, nausea, vomiting

Frequency not reported: Clostridium difficile-associated diarrhea, constipation, dry mouth, esophageal irritation, esophagitis, gastritis, pancreatitis, salivary gland enlargement[Ref]


Common (1% to 10%): Maculopapular rash, pruritus, rash, sweating increased

Uncommon (0.1% to 1%): Skin reaction

Frequency not reported: Facial edema, hyperhidrosis, itching, purpura, skin discoloration, sweats, urticaria[Ref]


Common (1% to 10%): ALT increased, AST increased, hepatotoxicity

Uncommon (0.1% to 1%): Hepatitis

Frequency not reported: Alkaline phosphatase increased, bilirubinemia, hepatomegaly, jaundice[Ref]


Common (1% to 10%): Coughing/cough, hemoptysis

Frequency not reported: Acute bronchospasm, asthma, bronchial hyperactivity, bronchospasm, dysphonia, dyspnea, epistaxis, laryngeal edema, laryngitis, oropharyngeal pain, pharyngitis, pneumonitis, pulmonary fibrosis, shortness of breath[Ref]

Nervous system

Common (1% to 10%): Dizziness, headache

Frequency not reported: Convulsion, paresthesia, peripheral neuropathy, somnolence, syncope[Ref]


Common (1% to 10%): Arthralgia, back pain

Frequency not reported: Arthritis, muscle pain, myalgia, myositis, rhabdomyolysis[Ref]


Common (1% to 10%): Hypersensitivity/hypersensitivity reaction

Frequency not reported: Anaphylaxis, angioedema[Ref]


Common (1% to 10%): Fever

Frequency not reported: Abortion, aches, asthenia, body fluid discoloration, chills, death, fatigue, feeling jittery, pyrexia, weakness[Ref]


Common (1% to 10%): Anorexia

Frequency not reported: Decreased appetite, gout, hyperglycemia, hyperkalemia, hyperlipidemia, hyperuricemia, porphyria[Ref]


Common (1% to 10%): Nonprotein nitrogen increased

Frequency not reported: Azotemia, blood urea nitrogen (BUN) increased[Ref]


Common (1% to 10%): Conjunctivitis[Ref]


Frequency not reported: Chest pain, flushing, hematoma, hypotension, orthostatic hypotension, palpitation, pericarditis, tachycardia, thrombosis[Ref]


Frequency not reported: Anxiety, confusion, depression, disorientation, suicidal ideation[Ref]


Frequency not reported: Hematuria, leukorrhea, vaginal hemorrhage, vaginitis, vulvovaginal candidiasis, vulvovaginal pruritus[Ref]


Frequency not reported: Flu-like syndrome, fungal infection, viral infection[Ref]


1. "Product Information. Priftin (rifapentine)." Hoechst Marion-Roussel Inc, Kansas City, MO.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.