Prevduo Side Effects
Generic name: glycopyrrolate / neostigmine
Medically reviewed by Drugs.com. Last updated on Apr 12, 2025.
Note: This document provides detailed information about Prevduo.
Applies to glycopyrrolate / neostigmine: intravenous solution Side Effects associated with glycopyrrolate / neostigmine. Some dosage forms listed on this page may not apply specifically to the brand name Prevduo.
Applies to glycopyrrolate / neostigmine: intravenous solution.
Precautions
Your doctor will check your progress closely while your or your child are receiving this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.
Check with your doctor right away if blurred vision, difficulty with reading, sensitivity of the eyes to light, or any other change in vision occurs during or after treatment. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor).
This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Check with your doctor right away if you or your child has chest tightness, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, skin rash, trouble breathing, or unusual tiredness or weakness.
This medicine may make you dizzy, drowsy, or cause blurred vision. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
This medicine may make you sweat less, which can cause your body temperature to rise. Be careful when you exercise and during hot weather. You could overheat or get heat stroke. Check with your doctor right away if you or your child has dizziness, fast, shallow breathing, fast, weak heartbeat, headache, muscle cramps, pale, clammy skin, thirst, or extremely high fever or body temperature.
Check with your doctor right away if you or your child have diarrhea or stomach pain. These may be symptoms of a serious stomach or bowel problem (eg, blockage).
This medicine may cause tachycardia. Check with your doctor right away if you have fast, pounding, or irregular heartbeat or pulse.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.
Serious side effects of Prevduo
Along with its needed effects, glycopyrrolate/neostigmine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking glycopyrrolate / neostigmine:
Less common side effects
- blurred vision
- change in color vision
- chest pain, discomfort, or tightness
- confusion
- cough
- decrease in frequency of urination
- decrease in urine volume
- difficult and painful urination
- difficulty in passing urine [dribbling]
- difficulty seeing at night
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- excitement
- fast, pounding, or irregular heartbeat or pulse
- headache
- hives, itching, skin rash
- increased sensitivity of eyes to sunlight
- mental confusion
- pale skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- sleeplessness
- slow or irregular heartbeat
- sweating
- thirst
- trouble breathing
- trouble sleeping
- unusual tiredness or weakness
Incidence not known
- constricted, pinpoint, or small pupils [black part of the eye]
- diarrhea
- high fever
- loss of consciousness
- no blood pressure or pulse
- no breathing
- noisy breathing
- pale or blue lips, fingernails, or skin
- rigid muscles
- seizures
- sleepiness
- stopping of the heart
- unconsciousness
Other side effects of Prevduo
Some side effects of glycopyrrolate / neostigmine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common side effects
- bloated
- constipation
- dry skin
- loss of taste
- nausea
- vomiting
Incidence not known
- difficulty in moving
- excess air or gas in the stomach or intestines
- feeling of warmth
- full feeling
- increased sweating
- joint pain
- muscle pain, stiffness, cramps, or spasms
- passing gas
- redness of the face, neck, arms and occasionally, upper chest
For healthcare professionals
Applies to glycopyrrolate / neostigmine: intravenous solution.
General adverse events
The most common adverse effects of glycopyrrolate (glycopyrronium) include xerostomia, urinary hesitancy and retention, blurred vision, and photophobia due to mydriasis, cycloplegia, increased ocular tension, tachycardia, bradycardia, and decreased sweating. The most common adverse effects of neostigmine are bradycardia, nausea, vomiting, blurred vision, and photophobia.[Ref]
Cardiovascular
- Common (1% to 10%): Increased/decreased heart rate
- Uncommon (0.1% to 1%): Supraventricular extrasystoles, ventricular extrasystoles (0.4%), procedural hypertension, chest discomfort, bradycardia, hypertension
Glycopyrrolate (glycopyrronium):
- Frequency not reported: Tachycardia, palpitation
- Postmarketing reports: Arrhythmias (including bradycardia, ventricular tachycardia, ventricular fibrillation), cardiac arrest, hypertension, hypotension, heart block, QTc interval prolongation
Neostigmine:
- Frequency not reported: Bradycardia, hypotension, tachycardia/increased heart rate
- Postmarketing reports: Cardiac arrest, cardiac arrhythmias (A-V block, nodal rhythm), hypotension, nonspecific electrocardiogram (EKG) changes, syncope[Ref]
Dermatologic
- Uncommon (0.1% to 1%): Hyperhidrosis, erythema, pruritus
Glycopyrrolate (glycopyrronium):
- Frequency not reported: Decreased sweating, urticaria, pruritus, dry skin
- Postmarketing reports: Pruritus, edema, erythema, pain at the injection site
Neostigmine:
- Frequency not reported: Pruritus
- Postmarketing reports: Rash, urticaria, flushing increased diaphoresis[Ref]
Gastrointestinal
- Common (1% to 10%): Nausea, dry mouth
- Uncommon (0.1% to 1%): Abdominal pain, dyspepsia, vomiting
Glycopyrrolate (glycopyrronium):
- Frequency not reported: Xerostomia, nausea, vomiting, constipation, bloated feeling
Neostigmine:
- Frequency not reported: Dry mouth, nausea, post-procedural nausea, vomiting, increased salivation
- Postmarketing reports: Bowel cramps, diarrhea, flatulence, increased peristalsis[Ref]
Musculoskeletal
- Common (1% to 10%): Muscle weakness
Neostigmine:
- Postmarketing reports: Arthralgia, muscle cramps, spasms, weakness[Ref]
Genitourinary
Glycopyrrolate (glycopyrronium):
- Frequency not reported: Urinary hesitancy and retention, impotence, micturition urgency
Neostigmine:
- Postmarketing reports: Urinary frequency[Ref]
Hepatic
- Uncommon (0.1% to 1%): Increased glutamyl transferase[Ref]
Hypersensitivity
Glycopyrrolate (glycopyrronium):
- Frequency not reported: Severe allergic reactions (including anaphylactic/anaphylactoid reactions), hypersensitivity
Neostigmine:
- Postmarketing reports: Allergic reactions (including anaphylaxis), hypersensitivity, angioedema[Ref]
Nervous system
- Uncommon (0.1% to 1%): Involuntary muscle contraction, somnolence, prolonged neuromuscular blockade
- Frequency not reported: Confusion (especially in elderly adults)
Glycopyrrolate (glycopyrronium):
- Frequency not reported: Loss of taste, headache, nervousness, drowsiness, dizziness
Neostigmine:
- Frequency not reported: Dizziness, headache, prolonged neuromuscular blockade[Ref]
Ocular
- Uncommon (0.1% to 1%): Visual accommodation disorder
- Frequency not reported: Dilatation of the pupils, angle closure glaucoma
Glycopyrrolate (glycopyrronium):
- Frequency not reported: Blurred vision, photophobia (due to mydriasis), cycloplegia, increased ocular tension[Ref]
Other
- Uncommon (0.1% to 1%): Decreased blood total protein, increased urine beta 2 microglobulin, incision site complication
Glycopyrrolate (glycopyrronium):
- Frequency not reported: Weakness, suppression of lactation
- Postmarketing reports: Malignant hyperthermia
Neostigmine:
- Frequency not reported: Procedural complication, procedural pain, incision site complication, postoperative shivering[Ref]
Psychiatric
- Uncommon (0.1% to 1%): Restlessness, sleep disorder, dizziness
Glycopyrrolate (glycopyrronium):
- Frequency not reported: Insomnia, mental confusion/excitement (especially in elderly adults)
Neostigmine:
- Frequency not reported: Insomnia[Ref]
Renal
- Uncommon (0.1% to 1%): Albuminuria[Ref]
Respiratory
- Uncommon (0.1% to 1%): Productive cough
Glycopyrrolate (glycopyrronium):
- Postmarketing reports: Respiratory arrest, decreased bronchial secretion
Neostigmine:
- Frequency not reported: Pharyngolaryngeal pain, dyspnea, less than 90% oxygen desaturation, increased oropharyngeal secretion
- Postmarketing reports: Bronchospasm (increased oral, pharyngeal, and bronchial secretions), respiratory arrest, respiratory depression[Ref]
See also:
Sugammadex
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Bridion
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Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Prostigmin Bromide
Prostigmin Bromide is used for myasthenia gravis, urinary retention
Neostigmine
Neostigmine systemic is used for myasthenia gravis, reversal of neuromuscular blockade, reversal of ...
References
1. (2023) "Product Information. Prevduo (glycopyrrolate-neostigmine)." Slayback Pharma LLC
2. (2019) "Product Information. Novistig (glycopyrronium-neostigmine)." Boucher & Muir Pty Ltd
3. (2019) "Product Information. Robinul-Neostigmine (glycopyrronium-neostigmine)." Advanz Pharma
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Further information
Prevduo side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.