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Platinol-AQ Side Effects

Generic name: cisplatin

Medically reviewed by Last updated on Jun 16, 2023.

Note: This document contains side effect information about cisplatin. Some dosage forms listed on this page may not apply to the brand name Platinol-AQ.

Applies to cisplatin: intravenous powder for solution, intravenous solution.


Intravenous route (Powder for Solution)

Nephrotoxicity: cisplatin injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Consider dose reductions or alternative treatments in patients with renal impairment.Peripheral Neuropathy: cisplatin injection can cause dose-related peripheral neuropathy.Nausea and Vomiting: cisplatin injection can cause severe nausea and vomiting. Premedicate with antiemetics.Myelosuppression: cisplatin injection can cause severe myelosuppression with fatalities due to infections. Monitor blood counts and interrupt therapy accordingly.

Serious side effects of Platinol-AQ

Along with its needed effects, cisplatin (the active ingredient contained in Platinol-AQ) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cisplatin:

More common

Incidence not known

Other side effects of Platinol-AQ

Some side effects of cisplatin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

For Healthcare Professionals

Applies to cisplatin: compounding powder, intravenous powder for injection, intravenous solution.


Very common (10% or more): Renal toxicity (36%)

Frequency not reported: Renal failure acute, renal tubular disorder[Ref]


Very common (10% or more): Nausea, vomiting, diarrhea

Rare (less than 0.1%): Stomatitis

Frequency not reported: Anorexia, hiccups[Ref]

Nervous system

Rare (less than 0.1%): Convulsion, neuropathy peripheral, leukoencephalopathy, reversible posterior leukoencephalopathy syndrome

Frequency not reported: Cerebrovascular accident, hemorrhagic stroke, ischemic stroke ageusia, cerebral arteritis, Lhermitte's sign, myelopathy, autonomic neuropathy[Ref]


Very common (10% or more): Leukopenia, thrombocytopenia, anemia

Frequency not reported: Coombs positive hemolytic anemia[Ref]


Frequency not reported: Vision blurred, color blindness acquired, blindness cortical, optic neuritis, papilledema, retinal pigmentation[Ref]


Uncommon (0.1% to 1%): Anaphylactoid reaction[Ref]


Very rare (less than 0.01%): Hepatic enzymes increased, blood bilirubin increased[Ref]


Common (1% to 10%): Local soft tissue toxicity (e.g., cellulitis, fibrosis, necrosis, pain, edema, erythema) as the result of extravasation[Ref]


Very rare (less than 0.01%): Cardiac arrest

Frequency not reported: Cardiac disorder, arrhythmia, bradycardia, tachycardia, thrombotic microangiopathy (hemolytic uremic syndrome), Raynaud's phenomenon[Ref]


Uncommon (0.1% to 1%): Abnormal spermatogenesis

Frequency not reported: Blood amylase increased, inappropriate antidiuretic hormone secretion[Ref]


Frequency not reported: Rash, alopecia[Ref]


Very common (10% or more): Anorexia, hyponatremia

Uncommon (0.1% to 1%): Hypomagnesemia

Frequency not reported: Dehydration, hypokalemia, hypophosphatemia, hyperuricemia, hypocalcemia, tetany[Ref]


Common (1% to 10%): Sepsis

Frequency not reported: Infection[Ref]


Frequency not reported: Muscle spasms[Ref]


Rare (less than 0.1%): Acute leukemia[Ref]


Frequency not reported: Pulmonary embolism, wheezing[Ref]


Very common (10% or more): Tinnitus and/or high frequency hearing loss (31%), pyrexia

Frequency not reported: Tinnitus, deafness[Ref]


1. (2018) "Product Information. Cisplatin (cisplatin)." Teva SICOR Pharmaceuticals Inc

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.