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Pancof Side Effects

Generic name: chlorpheniramine / dihydrocodeine / pseudoephedrine

Note: This document contains side effect information about chlorpheniramine / dihydrocodeine / pseudoephedrine. Some dosage forms listed on this page may not apply to the brand name Pancof.

Applies to chlorpheniramine/dihydrocodeine/pseudoephedrine: oral syrup.

Warning

You should not use this medication if you are allergic to chlorpheniramine, dihydrocodeine, pseudoephedrine, or codeine, or if you have severe or uncontrolled high blood pressure, severe coronary artery disease, narrow-angle glaucoma, a stomach ulcer, a bowel obstruction called paralytic ileus, bladder obstruction or other urination problems, overactive thyroid, or asthma, pneumonia, or other breathing problems.

Before you take chlorpheniramine, dihydrocodeine, and pseudoephedrine, tell your doctor about all of your medical conditions and other medicines you use.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Do not take this medication with alcohol, other narcotic pain medications, sedatives, tranquilizers, muscle relaxers, or other medicines that can make you sleepy or slow your breathing. Dangerous side effects may result.

Dihydrocodeine may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it.

Ask a doctor or pharmacist before using any other cold, cough, allergy, or pain medicine. Antihistamines, decongestants, and cough suppressants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine, decongestant, or cough suppressant.

This medication may cause blurred vision and may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Get emergency medical help if you have any of these signs of an allergic reaction while taking chlorpheniramine / dihydrocodeine / pseudoephedrine: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have a serious side effect such as:

Less serious side effects of chlorpheniramine / dihydrocodeine / pseudoephedrine may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to chlorpheniramine / dihydrocodeine / pseudoephedrine: oral syrup.

General

General side effects including light-headedness, dizziness, drowsiness, headache, fatigue, and sedation have been among the most frequently reported with opioid use. Confusion, abdominal pain, lassitude, giddiness, increased irritability or excitement (especially in children) have been reported. Hallucinations, severe narcosis, and vivid dreams have been reported rarely.[Ref]

Gastrointestinal

Gastrointestinal side effects of chlorpheniramine have included dry mouth and constipation in up to one-third of treated patients.

Gastrointestinal side effects including nausea, vomiting, and constipation have been among the most frequently reported with opioid use. Diarrhea, dry mouth, indigestion, anorexia, spasm of biliary tract have been reported.

Gastrointestinal side effects of pseudoephedrine have included anorexia and gastric irritation in approximately 5% of patients. Dry mouth, nose, or throat have occurred in up to 15% of patients.[Ref]

Nervous system

Nearly all patients treated with chlorpheniramine experience drowsiness. This drowsiness may subside in some patients with extended use.

Few cases of dyskinesias and tremors, often of the face, have been reported in patients whose chronic use of chlorpheniramine extended over a period of 3 to 10 years. Some of these cases were only partially relieved by discontinuation of the drug. Haloperidol was successful in relieving symptoms.[Ref]

Nervous system side effects of chlorpheniramine have included drowsiness in 75% or more of treated patients. Dyskinesias have rarely been reported following chronic use of chlorpheniramine.

Nervous system side effects of pseudoephedrine have included insomnia in up to 30% of patients. Tremor, anxiety, nervousness, and headache have also been reported.[Ref]

Dermatologic

Dermatologic side effects including sweating, pruritus, and skin reactions have been among the most frequently reported with opioid use. Flushing has been reported.[Ref]

Other

Other side effects of dihydrocodeine have included psychological dependence, physical dependence, and tolerance have been reported to develop upon repeated administration.[Ref]

Symptoms of dihydrocodeine withdrawal consist of irritability, restlessness, insomnia, diaphoresis, anxiety, and palpitations.[Ref]

Renal

Renal side effects including granulomatous interstitial nephritis and acute renal failure have been reported rarely during dihydrocodeine administration.[Ref]

Cardiovascular

Cardiovascular side effects of chlorpheniramine have included hypotension, tachycardia, and palpitations.

Cardiovascular side effects of pseudoephedrine have included tachycardia. Some patients have developed hypertension and/or arrhythmias.[Ref]

Respiratory

Respiratory side effects including respiratory depression have been reported.[Ref]

Ocular

Ocular side effects including miosis and blurred vision have been reported.[Ref]

Genitourinary

Genitourinary side effects including urinary retention have been reported.[Ref]

Hypersensitivity

Hypersensitivity side effects including anaphylactoid reactions have been reported rarely.[Ref]

More about Pancof (chlorpheniramine / dihydrocodeine / pseudoephedrine)

Professional resources

Other brands

Coldcough Syrup

Related treatment guides

References

1. Product Information. Hydro-Tussin DHC (chlorpheniramine/dihydrocodeine/PSE). Ethex Corporation. 2022.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.