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Oxymetholone Side Effects

Medically reviewed by Last updated on Feb 2, 2023.

Applies to oxymetholone: oral tablet.


You should not use this medicine if you have severe liver or kidney disease, prostate cancer, male breast cancer, or female breast cancer with high levels of calcium in the blood.

Do not use oxymetholone if you are pregnant.

Long-term use of oxymetholone can cause liver tumors or blood-filled cysts in your liver or spleen. Call your doctor at once if you have upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes), or rapid weight gain (especially in your face and midsection).

Get emergency medical help if you have any of these signs of an allergic reaction while taking oxymetholone: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Long-term use of oxymetholone can cause liver tumors or blood-filled cysts in your liver or spleen. Call your doctor at once if you have:

Also call your doctor at once if you have:

Women receiving oxymetholone may develop male features, which could be irreversible if treatment is continued. If you are a woman taking oxymetholone, tell your doctor right away if you have:

Common side effects in both men and women may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to oxymetholone: oral tablet.


The more commonly reported adverse effects of androgen therapy in males is gynecomastia and excessive frequency and duration of penile erections; in women virilization including voice deepening.[Ref]


Frequency not reported: Edema with or without congestive heart failure[Ref]


Frequency not reported: Phallic enlargement and increased frequency of erections (prepubertal); inhibition of testicular function, testicular atrophy and oligospermia, impotence, chronic priapism, epididymitis, bladder irritability and decrease in seminal volume. excessive frequency and duration of penile erections, oligospermia, increased or decreased libido (postpubertal); clitoral enlargement, menstrual irregularities (women); increased or decreased libido (both sexes)[Ref]


Rare (less than 0.1%): Peliosis hepatic, hepatic necrosis and death

Frequency not reported: Cholestatic jaundice, altered liver function[Ref]


Frequency not reported: Male pattern baldness, acne[Ref]


Frequency not reported: Premature closure of epiphyses in children, muscle spasms[Ref]


Frequency not reported: Hepatocellular neoplasms[Ref]


Frequency not reported: Suppression of clotting factors II, V, VII, and X; bleeding (in patients on concomitant anticoagulant therapy and polycythemia), anemia, leukemia (in patients with aplastic anemia)[Ref]


Frequency not reported: Gynecomastia, virilization (women), hirsutism[Ref]


Frequency not reported: Retention of sodium, chloride, potassium, calcium, phosphates, increased serum cholesterol, hypercalcemia, decreased glucose tolerance[Ref]


Frequency not reported: Increased creatine and creatine excretion[Ref]


Frequency not reported: Nausea, vomiting, diarrhea[Ref]


Frequency not reported: Excitation, insomnia[Ref]


Frequency not reported: Chills[Ref]

More about oxymetholone

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1. Product Information. Anadrol-50 (oxymetholone). Unimed Pharmaceuticals. PROD.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.