Oxymetazoline Topical Side Effects

Medically reviewed by Drugs.com. Last updated on Apr 3, 2025.

Applies to oxymetazoline topical: topical application cream.

Precautions

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to use it.

If your condition does not improve within a few days, or if it becomes worse, check with your doctor.

You will also need to have your blood pressure measured before starting this medicine and while you are using it. If you notice any change to your recommended blood pressure, call your doctor right away. If you have questions about this, talk to your doctor.

Check with your doctor immediately if blurred vision, eye pain, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor).

Do not use this medicine for a skin problem that has not been checked by your doctor.

Do not use cosmetics or other skin care products on the treated skin areas.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Serious side effects

Along with its needed effects, oxymetazoline topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oxymetazoline topical:

For healthcare professionals

Applies to oxymetazoline topical: topical cream.

Local adverse events

• Common (1% to 10%): Application site dermatitis/pruritus/pain
• Uncommon (0.1% to 1%): Application site erythema^[Ref]

Dermatologic

• Common (1% to 10%): Worsening inflammatory lesions of rosacea^[Ref]

See also:

Further information

Oxymetazoline topical side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer