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Oxymetazoline topical Side Effects

Medically reviewed by Last updated on Apr 6, 2023.

Applies to oxymetazoline topical: topical application cream.

Serious side effects

Along with its needed effects, oxymetazoline topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oxymetazoline topical:

Less common

  • Blistering, crusting, irritation, itching, or reddening of the skin
  • cracked, dry, scaly skin
  • swelling or pain at the application site
  • worsening of rosacea pimples

For Healthcare Professionals

Applies to oxymetazoline topical: topical cream.


Common (1% to 10%): Application site dermatitis/pruritus/pain

Uncommon (0.1% to 1%): Application site erythema[Ref]


Common (1% to 10%): Worsening inflammatory lesions of rosacea[Ref]


1. Product Information. Rhofade (oxymetazoline topical). Allergan Inc. 2017.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.