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Otiprio Side Effects

Generic Name: ciprofloxacin otic

Note: This page contains side effects data for the generic drug ciprofloxacin otic. It is possible that some of the dosage forms included below may not apply to the brand name Otiprio.

For the Consumer

Applies to ciprofloxacin otic: intratympanic suspension

Other dosage forms:

As well as its needed effects, ciprofloxacin otic (the active ingredient contained in Otiprio) may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking ciprofloxacin otic, check with your doctor or nurse immediately:

Less common:
  • Fever
  • headache
  • muscle aches
  • sore throat
  • stuffy or runny nose
  • unusual tiredness or weakness

Minor Side Effects

Some ciprofloxacin otic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Irritability

For Healthcare Professionals

Applies to ciprofloxacin otic: otic solution, otic suspension


The most commonly reported side effects included localized pain, ear pruritus, superinfection, and headache.[Ref]


Common (1% to 10%): Ear pruritus, ear pain, ear discomfort/stinging, ear infection, fungal ear superinfection/otomycosis
Frequency not reported: Facial edema
Postmarketing reports: Crying, ear congestion, otorrhea, tinnitus, pyrexia[Ref]

Nervous system

Common (1% to 10%): Headache/cephalea, transient dizziness, vertigo, dysgeusia/bitter taste
Frequency not reported: Loss of consciousness, tingling[Ref]


Common (1% to 10%): Nasopharyngitis, rhinorrhea
Frequency not reported: Pharyngeal edema, dyspnea[Ref]


Common (1% to 10%): Mild local intolerance, application site pain[Ref]


Common (1% to 10%): Irritability[Ref]


Frequency not reported: Toxic epidermolysis, exfoliative dermatitis, rash, Stevens-Johnson syndrome, urticaria, itching
Postmarketing reports: Dermatitis[Ref]


Frequency not reported: Allergic reaction, anaphylactic reaction[Ref]


Frequency not reported: Cardiovascular collapse[Ref]


Frequency not reported: Tendon rupture[Ref]


1. Cerner Multum, Inc. "Australian Product Information." O 0

2. "Product Information. Cetraxal (ciprofloxacin otic)." WraSer Pharmaceuticals, Madison, MS.

3. "Product Information. Otiprio (ciprofloxacin otic)." Otonomy, Inc., San Diego, CA.

It is possible that some side effects of Otiprio may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.