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Orvaten Side Effects

Generic Name: midodrine

Note: This page contains side effects data for the generic drug midodrine. It is possible that some of the dosage forms included below may not apply to the brand name Orvaten.

For the Consumer

Applies to midodrine: oral tablet

As well as its needed effects, midodrine (the active ingredient contained in Orvaten) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking midodrine, check with your doctor immediately:

More common:
  • Blurred vision
  • cardiac awareness
  • headache
  • pounding in the ears
  • Fainting
  • increased dizziness
  • slow pulse

Minor Side Effects

Some midodrine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Burning, itching, or prickling of the scalp
  • chills
  • goosebumps
  • urinary frequency, retention, or urgency
Less common:
  • Anxiety or nervousness
  • confusion
  • dry mouth
  • flushing
  • headache or feeling of pressure in the head
  • skin rash
  • Backache
  • canker sores
  • dizziness
  • drowsiness
  • dry skin
  • leg cramps
  • pain or sensitivity of the skin to touch
  • stomach problems such as gas, heartburn, or nausea
  • trouble seeing
  • trouble with sleeping
  • weakness

For Healthcare Professionals

Applies to midodrine: oral tablet


Marked elevation of supine arterial blood pressure is potentially the most serious side effect reported with midodrine (the active ingredient contained in Orvaten) therapy. The manufacturer reports a systolic pressure of 200 mmHg in 13.4% of patients receiving midodrine 10 mg orally. Patients with a mean pretreatment systolic pressure of 170 mmHg were more prone to this effect. There is no experience of midodrine administered to patients with a pretreatment systolic pressure over 180 mmHg.

The patient may be able to control supine hypertension by avoiding a full supine position.

Symptoms of supine hypertension may included, but are not limited to, cardiac awareness, pounding in the ears, headache, and blurred vision.[Ref]

Cardiovascular side effects have frequently included supine and sitting hypertension.[Ref]

Nervous system

Nervous system side effects have frequently included paresthesia (18.3%). Confusion, abnormal thinking, nervousness, and anxiety have also been reported. Dizziness, skin hyperesthesia, insomnia, and somnolence have been reported rarely.[Ref]


Scalp pruritus is the most common form of pruritus reported by patients.[Ref]

Dermatologic side effects have frequently included piloerection (13.4%) and pruritus (12.2%). Rash has been reported in 2.4% of patients. Erythema multiforme and dry skin have been reported rarely.[Ref]


Other side effects have frequently included chills (4.9%) and pain/increase in level of pain (4.9%). Headache, feeling of pressure/fullness in the head, vasodilation/flushing of face, and dry mouth have also been reported. Leg cramps, canker sore, and backache have been reported rarely.[Ref]


Reports of dysuria have included urinary urge, urinary retention, urinary frequency, and impaired urination.[Ref]

Genitourinary side effects have frequently included dysuria (13.4%).[Ref]


Ocular side effects have rarely included visual field defect.[Ref]


Gastrointestinal side effects have rarely included pyrosis, nausea, gastrointestinal distress, and flatulence.[Ref]


Musculoskeletal side effects have rarely included asthenia.[Ref]


1. "Product Information. ProAmatine (midodrine)." Roberts Pharmaceutical Corporation, Eatontown, NJ.

It is possible that some side effects of Orvaten may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.