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Orvaten Side Effects

Generic Name: midodrine

Note: This document contains side effect information about midodrine. Some of the dosage forms listed on this page may not apply to the brand name Orvaten.

For the Consumer

Applies to midodrine: oral tablet

Along with its needed effects, midodrine (the active ingredient contained in Orvaten) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking midodrine:

More common
  • Blurred vision
  • cardiac awareness
  • headache
  • pounding in the ears
Rare
  • Fainting
  • increased dizziness
  • slow pulse

Some side effects of midodrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Burning, itching, or prickling of the scalp
  • chills
  • goosebumps
  • urinary frequency, retention, or urgency
Less common
  • Anxiety or nervousness
  • confusion
  • dry mouth
  • flushing
  • headache or feeling of pressure in the head
  • skin rash
Rare
  • Backache
  • canker sores
  • dizziness
  • drowsiness
  • dry skin
  • leg cramps
  • pain or sensitivity of the skin to touch
  • stomach problems such as gas, heartburn, or nausea
  • trouble seeing
  • trouble with sleeping
  • weakness

For Healthcare Professionals

Applies to midodrine: oral tablet

General

The most common adverse reactions were paresthesia (includes hyperesthesia and scalp paresthesia), piloerection, dysuria (includes dysuria, increased urinary frequency, impaired urination, urinary retention, and urinary urgency), pruritus (includes scalp pruritus), and supine hypertension.[Ref]

Cardiovascular

Common (1% to 10%): Supine hypertension, flushing
Uncommon (0.1% to 1%): Reflex bradycardia
Rare (less than 0.1%): Tachycardia, palpitations
Frequency not reported: Vasodilation/flushing face[Ref]

Nervous system

Very common (10% or more): Paresthesia (18.3%)
Common (1% to 10%): Headache
Frequency not reported: Feeling of pressure/fullness in the head, dizziness, somnolence[Ref]

Dermatologic

Very common (10% or more): Piloerection (13.4%), pruritus (12.2%)
Common (1% to 10%): Rash
Frequency not reported: Skin hyperesthesia, erythema multiforme, dry skin[Ref]

Genitourinary

Very common (10% or more): Dysuria (13.4%)
Frequency not reported: Impaired urination[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, dyspepsia, stomatitis
Frequency not reported: Dry mouth, canker sore, pyrosis, gastrointestinal distress, flatulence, abdominal pain, vomiting, diarrhea[Ref]

Other

Common (1% to 10%): Chills, pain
Frequency not reported: Asthenia[Ref]

Psychiatric

Uncommon (0.1% to 1%): Sleep disorders, insomnia, restlessness, excitability, irritability
Frequency not reported: Confusion/thinking abnormality, nervousness/anxiety[Ref]

Hepatic

Rare (less than 0.1%): Abnormal hepatic function, raised liver enzymes[Ref]

Musculoskeletal

Frequency not reported: Backache, leg cramps[Ref]

Ocular

Frequency not reported: Visual field defect[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. "Product Information. ProAmatine (midodrine)." Roberts Pharmaceutical Corporation, Eatontown, NJ.

Some side effects of Orvaten may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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