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OptiMARK Side Effects

Generic name: gadoversetamide

Medically reviewed by Last updated on Aug 23, 2022.

Note: This document contains side effect information about gadoversetamide. Some dosage forms listed on this page may not apply to the brand name OptiMARK.

Applies to gadoversetamide: intravenous solution.

Nervous system

Nervous system side effects have included headache, dizziness, paresthesia, agitation, anxiety, confusion, depersonalization, dystonia, hallucinations, hypertonia, hypesthesia, nervousness, somnolence, tremor, hyperacusis, parosmia, tinnitus, seizure, and vertigo.[Ref]


Cardiovascular side effects have included vasodilatation, arrhythmia, chest pain, hypertension, hypotension, pallor, palpitation, syncope, tachycardia, and vasospasm.[Ref]


Gastrointestinal side effects have included taste perversion, nausea, anorexia, increased appetite, constipation, dry mouth, dysphagia, eructation, flatulence, increased salivation, thirst, and vomiting.[Ref]


Ocular side effects have included diplopia, amblyopia, and conjunctivitis.[Ref]


Respiratory side effects have included asthma, cough, dyspnea, epistaxis, hemoptysis, laryngismus, pharyngitis, sinusitis, and voice alteration.[Ref]


Local side effects have included application site reaction, injection site edema and inflammation.[Ref]


Dermatologic side effects have included erythema multiforme, pruritus, macular papular rash, vesicullous bullous rash, skin dry, thrombophlebitis, and urticaria.[Ref]


Musculoskeletal side effects have included arthralgia, leg cramps, myalgia, myasthenia, and spasm.[Ref]


Genitourinary side effects have included dysuria, oliguria, and urine frequency.[Ref]


Metabolic side effects have included increased creatinine, edema, hypercalcemia, hyperglycemia, hypoglycemia, and hyponatremia.[Ref]


Hematologic side effects have included thrombocytopenia.[Ref]


Hypersensitivity side effects have included allergic reaction, facial edema, fever, flu-like syndrome, malaise, mucous membrane discharge, neck rigidity, neck pain, pelvic pain, and increased sweating.[Ref]


1. "Product Information. OptiMARK (gadoversetamide)." Mallinckrodt Medical Inc (2010):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.