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OptiMARK Side Effects

Generic Name: gadoversetamide

Note: This document contains side effect information about gadoversetamide. Some of the dosage forms listed on this page may not apply to the brand name OptiMARK.

For the Consumer

Applies to gadoversetamide: intravenous solution

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Very bad dizziness or passing out.
  • Flushing.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Headache.
  • Change in taste.
  • Pain where the shot was given.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to gadoversetamide: intravenous solution

Nervous system

Nervous system side effects have included headache, dizziness, paresthesia, agitation, anxiety, confusion, depersonalization, dystonia, hallucinations, hypertonia, hypesthesia, nervousness, somnolence, tremor, hyperacusis, parosmia, tinnitus, seizure, and vertigo.[Ref]

Cardiovascular

Cardiovascular side effects have included vasodilatation, arrhythmia, chest pain, hypertension, hypotension, pallor, palpitation, syncope, tachycardia, and vasospasm.[Ref]

Gastrointestinal

Gastrointestinal side effects have included taste perversion, nausea, anorexia, increased appetite, constipation, dry mouth, dysphagia, eructation, flatulence, increased salivation, thirst, and vomiting.[Ref]

Ocular

Ocular side effects have included diplopia, amblyopia, and conjunctivitis.[Ref]

Respiratory

Respiratory side effects have included asthma, cough, dyspnea, epistaxis, hemoptysis, laryngismus, pharyngitis, sinusitis, and voice alteration.[Ref]

Local

Local side effects have included application site reaction, injection site edema and inflammation.[Ref]

Dermatologic

Dermatologic side effects have included erythema multiforme, pruritus, macular papular rash, vesicullous bullous rash, skin dry, thrombophlebitis, and urticaria.[Ref]

Musculoskeletal

Musculoskeletal side effects have included arthralgia, leg cramps, myalgia, myasthenia, and spasm.[Ref]

Genitourinary

Genitourinary side effects have included dysuria, oliguria, and urine frequency.[Ref]

Metabolic

Metabolic side effects have included increased creatinine, edema, hypercalcemia, hyperglycemia, hypoglycemia, and hyponatremia.[Ref]

Hematologic

Hematologic side effects have included thrombocytopenia.[Ref]

Hypersensitivity

Hypersensitivity side effects have included allergic reaction, facial edema, fever, flu-like syndrome, malaise, mucous membrane discharge, neck rigidity, neck pain, pelvic pain, and increased sweating.[Ref]

References

1. "Product Information. OptiMARK (gadoversetamide)." Mallinckrodt Medical Inc, St. Louis, MO.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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