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Gadoversetamide use while Breastfeeding

Drugs containing Gadoversetamide: OptiMARK

Gadoversetamide Levels and Effects while Breastfeeding

Summary of Use during Lactation

There is no published experience with gadoversetamide during breastfeeding. Gadoversetamide releases more free gadolinium than most other gadolinium-containing contrast agents and European sources recommend that the mother pump and discard milk for 24 hours after receiving gadoversetamide.[1][2] However, guidelines developed by several North American professional organizations state that breastfeeding need not be disrupted after a nursing mother receives a gadolinium-containing contrast medium.[3][4][5] Other agents may be preferred, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Gadobutrol, Gadopentetate, Gadoteridol, Gadoterate

References

1. Webb JA, Thomsen HS. Gadolinium contrast media during pregnancy and lactation. Acta Radiol. 2013;54:599-600. PMID: 23966544

2. European Society of Urogenital Radiology. ESUR guidelines on contrast media. 2012;Version 8.0. http://www.esur.org/guidelines

3. American College of Radiology Committee on Drugs and Contrast Media. Administration of contrast media to breast-feeding mothers. In, ACR manual on contrast media. 2015;Version 10.1:99-100. http://www.acr.org/~/media/ACR/Documents/PDF/QualitySafety/Resources/Contrast%20Manual/2015_Contrast_Media.pdf

4. Patenaude Y, Pugash D, Lim K et al. The use of magnetic resonance imaging in the obstetric patient. J Obstet Gynaecol Can. 2014;36:349-55. PMID: 24798674

5. Committee Opinion No. 656: Guidelines for Diagnostic Imaging During Pregnancy and Lactation. Obstet Gynecol. 2016;127:e75-80. PMID: 26942391

Gadoversetamide Identification

Substance Name

Gadoversetamide

CAS Registry Number

131069-91-5

Drug Class

Contrast Media

Diagnostic Agents

Administrative Information

LactMed Record Number

531

Last Revision Date

20160819

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy.

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