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Gadoversetamide Side Effects

Medically reviewed by Drugs.com. Last updated on Jul 12, 2021.

For the Consumer

Applies to gadoversetamide: intravenous solution

Warning

Gadoversetamide can cause a life-threatening condition in people with advanced kidney disease. You should not receive this medication if you have kidney disease or if you are on dialysis.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects of gadoversetamide may occur up to several days after injection.

Gadoversetamide can cause a life-threatening condition in people with advanced kidney disease. Call your doctor right away if you have any symptoms of this condition, such as:

  • burning, itching, swelling, scaling, and tightening or hardening of your skin;

  • muscle weakness;

  • joint stiffness in your arms, hands, legs, or feet;

  • deep bone pain in your ribs or your hips;

  • trouble moving; or

  • skin redness or discoloration.

Also call your doctor at once if you have:

  • kidney problems--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;

  • a seizure (convulsions); or

  • fast, uneven heart rate.

Common side effects may include:

  • headache, dizziness;

  • nausea;

  • flushing (warmth, redness, or tingly feeling);

  • unusual or unpleasant taste in your mouth; or

  • numbness, burning pain, or tingling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to gadoversetamide: intravenous solution

Nervous system

Nervous system side effects have included headache, dizziness, paresthesia, agitation, anxiety, confusion, depersonalization, dystonia, hallucinations, hypertonia, hypesthesia, nervousness, somnolence, tremor, hyperacusis, parosmia, tinnitus, seizure, and vertigo.[Ref]

Cardiovascular

Cardiovascular side effects have included vasodilatation, arrhythmia, chest pain, hypertension, hypotension, pallor, palpitation, syncope, tachycardia, and vasospasm.[Ref]

Gastrointestinal

Gastrointestinal side effects have included taste perversion, nausea, anorexia, increased appetite, constipation, dry mouth, dysphagia, eructation, flatulence, increased salivation, thirst, and vomiting.[Ref]

Ocular

Ocular side effects have included diplopia, amblyopia, and conjunctivitis.[Ref]

Respiratory

Respiratory side effects have included asthma, cough, dyspnea, epistaxis, hemoptysis, laryngismus, pharyngitis, sinusitis, and voice alteration.[Ref]

Local

Local side effects have included application site reaction, injection site edema and inflammation.[Ref]

Dermatologic

Dermatologic side effects have included erythema multiforme, pruritus, macular papular rash, vesicullous bullous rash, skin dry, thrombophlebitis, and urticaria.[Ref]

Musculoskeletal

Musculoskeletal side effects have included arthralgia, leg cramps, myalgia, myasthenia, and spasm.[Ref]

Genitourinary

Genitourinary side effects have included dysuria, oliguria, and urine frequency.[Ref]

Metabolic

Metabolic side effects have included increased creatinine, edema, hypercalcemia, hyperglycemia, hypoglycemia, and hyponatremia.[Ref]

Hematologic

Hematologic side effects have included thrombocytopenia.[Ref]

Hypersensitivity

Hypersensitivity side effects have included allergic reaction, facial edema, fever, flu-like syndrome, malaise, mucous membrane discharge, neck rigidity, neck pain, pelvic pain, and increased sweating.[Ref]

References

1. "Product Information. OptiMARK (gadoversetamide)." Mallinckrodt Medical Inc, St. Louis, MO.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.