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Ocuflox Side Effects

Generic Name: ofloxacin ophthalmic

Note: This document contains side effect information about ofloxacin ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Ocuflox.

For the Consumer

Applies to ofloxacin ophthalmic: ophthalmic solution

Along with its needed effects, ofloxacin ophthalmic (the active ingredient contained in Ocuflox) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ofloxacin ophthalmic:

  • Puffiness or swelling of eyes
  • signs of an allergic reaction, such as hives, itching, rash, swelling of face or lips, tightness in chest, troubled breathing, or wheezing

Check with your doctor as soon as possible if any of the following side effects occur while taking ofloxacin ophthalmic:


Some side effects of ofloxacin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Burning of eye
Less common
  • Blurred vision
  • eye pain
  • feeling of something in the eye
  • increased sensitivity of eye to light
  • redness, irritation, or itching of eye, eyelid, or inner lining of eyelid
  • stinging, tearing, or dryness of eye

For Healthcare Professionals

Applies to ofloxacin ophthalmic: ophthalmic solution


Burning/stinging, tearing, and eye pain were reported in up to 14%, up to 11%, and up to 5% of treated eyes, respectively.

Burning/stinging, tearing, photophobia, and foreign body sensation were reported more often in patients treated for corneal ulcer.[Ref]

Common (1% to 10%): Eye irritation, ocular discomfort
Frequency not reported: Transient ocular burning/discomfort, keratitis, conjunctivitis, eye edema, periorbital edema, foreign body sensation in eyes, dry eyes, ocular hyperemia, eye pruritus, eyelid pruritus, burning/stinging, redness, itching, chemical conjunctivitis/keratitis, ocular/periocular/facial edema, eye pain, photophobia, tearing, blurred vision, dryness
Postmarketing reports: Hypersensitivity, increased lacrimation[Ref]


Very rare (less than 0.01%)/Postmarketing reports: Hypersensitivity (including angioedema, dyspnea, anaphylactic reaction/shock, oropharyngeal swelling, swollen tongue)

Systemic ofloxacin:
-Frequency not reported: Hypersensitivity (anaphylactic/anaphylactoid) reactions

Serious and occasionally fatal hypersensitivity (anaphylactic/anaphylactoid) reactions (some after first dose) have been reported with systemic ofloxacin.


Ventricular arrhythmia and torsades de pointes were reported mainly in patients with risk factors for QT prolongation.

Frequency not reported: Ventricular arrhythmia, torsades de pointes, prolonged ECG QT

Nervous system

Frequency not reported: Dizziness[Ref]


Frequency not reported: Nausea[Ref]


Frequency not reported: Facial edema


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Ocuflox (ofloxacin ophthalmic)." Allergan Inc, Irvine, CA.

Some side effects of Ocuflox may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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