Nydrazid Side Effects
Generic Name: isoniazid
Note: This document contains side effect information about isoniazid. Some of the dosage forms listed on this page may not apply to the brand name Nydrazid.
For the Consumer
Applies to isoniazid: solution, syrup, tablet
Along with its needed effects, isoniazid (the active ingredient contained in Nydrazid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking isoniazid:
- Clumsiness or unsteadiness
- dark urine
- loss of appetite
- nausea or vomiting
- numbness, tingling, burning, or pain in hands and feet
- unusual tiredness or weakness
- yellow eyes or skin
- Blurred vision or loss of vision, with or without eye pain
- convulsions (seizures)
- fever and sore throat
- joint pain
- mental depression
- mood or other mental changes
- skin rash
- unusual bleeding or bruising
Some side effects of isoniazid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- stomach pain
For injection form
- Irritation at the place of injection
Dark urine and yellowing of the eyes or skin (signs of liver problems) are more likely to occur in patients over 50 years of age.
For Healthcare Professionals
Applies to isoniazid: intramuscular solution, oral syrup, oral tablet
Mild and transient elevation in serum transaminases usually occurred in the first 1 to 6 months of treatment, but could occur at any time during treatment. Transaminase levels returned to normal with continued treatment in most cases.[Ref]
Common (1% to 10%): Peripheral neuropathy
Peripheral neuropathy usually occurred with doses over 5 mg/kg.[Ref]
Very common (10% or more): Mild and transient elevation of serum transaminase levels (up to 20%)
Uncommon (0.1% to 1%): Hepatitis
Frequency not reported: Allergic skin reaction, alopecia, drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, erythema multiforme, exfoliative dermatitis, exfoliative skin eruptions, maculopapular skin eruptions, morbilliform skin eruptions, purpura, purpuric skin eruptions, rash, skin eruptions[Ref]
Frequency not reported: Fatigue, fever, malaise, weakness[Ref]
Frequency not reported: Psychosis, toxic psychosis[Ref]
Frequency not reported: Optic atrophy[Ref]
Frequency not reported: Bilirubinuria[Ref]
Frequency not reported: Gynecomastia[Ref]
Frequency not reported: Rheumatic syndrome[Ref]
Frequency not reported: Local irritation[Ref]
1. "Product Information. Nydrazid (isoniazid)" Apothecon Inc, Princeton, NJ.
2. "Product Information. Isoniazid (isoniazid)." Barr Laboratories Inc, Pomona, NY.
3. "Product Information. INH (isoniazid)." Ciba Pharmaceuticals, Summit, NJ.
4. Cerner Multum, Inc. "Australian Product Information." O 0
5. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Some side effects may not be reported. You may report them to the FDA.
More about Nydrazid (isoniazid)
- During Pregnancy or Breastfeeding
- Dosage Information
- Drug Interactions
- Drug class: hydrazide derivatives