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Norepinephrine Side Effects

For the Consumer

Applies to norepinephrine: parenteral injection

Side effects include:

May cause headache, anxiety, arrhythmias, bradycardia, respiratory difficulty, ischemic injury, or extravasation at the infusion site.

For Healthcare Professionals

Applies to norepinephrine: injectable solution, intravenous solution

General

If plasma volumes are not corrected, hypotension may recur when this drug is discontinued, or blood pressure may be maintained at the risk of severe peripheral and visceral vasoconstriction (e.g., decreased renal perfusion) with diminution in blood flow and tissue perfusion with subsequent tissue hypoxia and lactic acidosis and possible ischemic injury. Overdoses or conventional doses in hypersensitive patients (e.g., hyperthyroid patients) can cause severe hypertension with violent headache, photophobia, stabbing retrosternal pain, pallor, intense sweating, and vomiting.[Ref]

Local

Frequency not reported: Extravasation necrosis[Ref]

Cardiovascular

Frequency not reported: Ischemic injury, bradycardia, arrhythmia, blood pressure increased, hypertension, pallor, stabbing retrosternal pain[Ref]

Nervous system

Frequency not reported: Headache

Dermatologic

Frequency not reported: Sweating[Ref]

Gastrointestinal

Frequency not reported: Vomiting[Ref]

Ocular

Frequency not reported: Photophobia[Ref]

Metabolic

Frequency not reported: Plasma volume depletion[Ref]

Psychiatric

Frequency not reported: Anxiety[Ref]

Respiratory

Frequency not reported: Respiratory difficulty, dyspnea

Other

Frequency not reported: Gangrene[Ref]

References

1. "Product Information. Levophed (norepinephrine)." Hospira Inc, Lake Forest, IL.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

It is possible that some side effects of norepinephrine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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