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Nirogacestat Side Effects

Medically reviewed by Drugs.com. Last updated on Aug 6, 2024.

Applies to nirogacestat: oral tablets.

Side effects include:

Most common adverse reactions (incidence ≥15%): diarrhea, ovarian toxicity, rash, nausea, fatigue, stomatitis, headache, abdominal pain, cough, alopecia, upper respiratory tract infection, dyspnea.

For healthcare professionals

Applies to nirogacestat: oral tablet.

General adverse events

The most common reactions/laboratory abnormalities occurring in 15% of patients or greater included diarrhea, ovarian toxicity, rash, nausea, fatigue, stomatitis, headache, abdominal pain, cough, alopecia, upper respiratory tract infection, dyspnea, decreased phosphate, increased urine glucose, increased urine protein, increased AST, increased ALT, and decreased potassium.[Ref]

Dermatologic

Endocrine

Ovarian toxicity included ovarian failure, premature menopause, amenorrhea, and menopause.

Gastrointestinal

Hepatic

Metabolic

Oncologic

Other

Renal

Respiratory

Nervous system

References

1. (2023) "Product Information. Ogsiveo (nirogacestat)." SpringWorks Therapeutics, Inc.

Further information

Nirogacestat side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.