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Nirogacestat Dosage

Medically reviewed by Drugs.com. Last updated on Jul 8, 2024.

Applies to the following strengths: 50 mg; 100 mg; 150 mg

Usual Adult Dose for Fibromatosis

150 mg orally twice a day
Duration of therapy: Until disease progression or unacceptable toxicity

Use: For the treatment of progressing desmoid tumors in patients who require systemic therapy

Renal Dose Adjustments

Renal dysfunction: Data not available

Liver Dose Adjustments

Dose Modifications for Elevated Liver Enzymes:

Dose Adjustments

DOSE MODIFICATIONS FOR ADVERSE REACTIONS:
Diarrhea:


Hypophosphatemia:

Hypokalemia:

DOSE MODIFICATIONS FOR OTHER SEVERE, LIFE-THREATENING, OR PERSISTENT INTOLERABLE GRADE 2 ADVERSE EVENTS:

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Hemodialysis: This drug is highly bound to plasma proteins and not expected to be dialyzable.
Peritoneal dialysis: Data not available

Other Comments

Administration advice:


Storage requirements:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.