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Namzaric Side Effects

Generic Name: donepezil / memantine

Note: This page contains side effects data for the generic drug donepezil / memantine. It is possible that some of the dosage forms included below may not apply to the brand name Namzaric.

In Summary

Common side effects of Namzaric include: diarrhea. Other side effects include: dizziness, nausea, vomiting, anorexia, and ecchymoses. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to donepezil / memantine: oral capsule delayed release, oral capsule extended release

As well as its needed effects, donepezil / memantine may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking donepezil / memantine, check with your doctor immediately:

Incidence not known:
  • Bloody or black, tarry stools
  • chest pain or discomfort
  • decreased urination
  • lightheadedness, dizziness, or fainting
  • pain in the lower abdomen, groin, upper back or sides
  • seizures
  • severe stomach pain
  • slow or irregular heartbeat
  • sweating
  • trouble breathing
  • unusual tiredness
  • vomiting of blood or material that looks like coffee grounds

Minor Side Effects

Some donepezil / memantine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:
  • Constipation
  • decreased appetite
  • diarrhea
  • nausea
  • vomiting

For Healthcare Professionals

Applies to donepezil / memantine: oral capsule extended release, oral kit


Common (1% to 10%): Hypertension, hypotension
Postmarketing reports: Congestive cardiac failure

Common (1% to 10%): Hypertension, hemorrhage, syncope
Postmarketing reports: Heart block (all types)[Ref]

Nervous system

Common (1% to 10%): Headache, dizziness, somnolence

Common (1% to 10%): Headache, dizziness, somnolence
Postmarketing reports: Convulsions, neuroleptic malignant syndrome[Ref]


Common (1% to 10%): Diarrhea, constipation, abdominal pain, vomiting
Postmarketing reports: Pancreatitis

Very common (10% or more): Diarrhea (10%)
Common (1% to 10%): Vomiting, anorexia, nausea
Postmarketing reports: Abdominal pain, pancreatitis[Ref]


Common (1% to 10%): Influenza[Ref]


The most common adverse reactions in patients receiving memantine ER were headache, diarrhea, and dizziness. The most common adverse reactions in patients receiving donepezil were diarrhea, anorexia, vomiting, nausea, and ecchymosis.[Ref]


Postmarketing reports: Stevens Johnson Syndrome

Common (1% to 10%): Eczema
Postmarketing reports: Rash[Ref]


Postmarketing reports: Agranulocytosis, leukopenia (including neutropenia), pancytopenia, thrombocytopenia, thrombotic thrombocytopenic purpura

Common (1% to 10%): Ecchymosis
Postmarketing reports: Hemolytic anemia[Ref]


Postmarketing reports: Hepatitis

Postmarketing reports: Cholecystitis, hepatitis[Ref]


Common (1% to 10%): Increased creatinine phosphokinase, dehydration, hyperlipidemia
Postmarketing reports: Hyponatremia[Ref]


Common (1% to 10%): Back pain

Common (1% to 10%): Back pain[Ref]


Common (1% to 10%): Increased weight

Very common (10% or more): Accident (13%), infection (11%)
Common (1% to 10%): Fever, pain, chest pain[Ref]


Common (1% to 10%): Anxiety, depression, aggression
Postmarketing reports: Suicidal ideation

Common (1% to 10%): Insomnia, nervousness, hallucinations, hostility, depression, confusion, emotional lability, personality disorder
Postmarketing reports: Agitation, confusion, hallucinations[Ref]


Common (1% to 10%): Urinary incontinence
Postmarketing reports: Acute renal failure

Common (1% to 10%): Urinary incontinence[Ref]


1. "Product Information. Namzaric (donepezil-memantine)." Forest Pharmaceuticals, St. Louis, MO.

It is possible that some side effects of Namzaric may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.