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Naftin-MP Side Effects

Generic Name: naftifine topical

Note: This page contains side effects data for the generic drug naftifine topical. It is possible that some of the dosage forms included below may not apply to the brand name Naftin-MP.

For the Consumer

Applies to naftifine topical: topical cream, topical gel/jelly

As well as its needed effects, naftifine topical (the active ingredient contained in Naftin-MP) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking naftifine topical, check with your doctor immediately:

Less common:
  • Burning, stinging, itching, redness, or irritation of the skin
Incidence not known:
  • Blistering or crusting of the skin
  • softening of the skin

Minor Side Effects

Some naftifine topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Dizziness
  • headache
Less common:
  • Dry skin

For Healthcare Professionals

Applies to naftifine topical: topical cream, topical gel


The most common side effect reported with the 2% cream was pruritus. The most common side effects reported with the 2% gel were application site reactions.[Ref]


Common (1% to 10%): Burning/stinging, dryness, erythema, pruritus/itching
Uncommon (0.1% to 1%): Rash, skin tenderness
Postmarketing reports: Redness/irritation, erythema/redness, irritation, burning, blisters, crusting, dryness, mild pruritus/itching, rash[Ref]


Common (1% to 10%): Local irritation, application site reactions


Postmarketing reports: Inflammation, maceration, swelling, serous drainage, pain


Postmarketing reports: Leukopenia, agranulocytosis

Nervous system

Postmarketing reports: Headache, dizziness, burning sensation


1. "Product Information. Naftin (naftifine topical)" Merz Pharmaceuticals, Greensboro, NC.

2. "Product Information. Naftin (naftifine topical)" Merz Pharmaceuticals, Greenboro, NC.

It is possible that some side effects of Naftin-MP may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.